The current Fascicle contains new information accumulated during the last ten years on tumors and tumor-like lesions of the gallbladder, extrahepatic bile ducts and Vaterian system. Because of the increasing number of laparoscopic cholecystectomies and Whipple procedures performed, surgical pathologists now have the opportunity to examine more cancer precursors, early cancers, and adenomas of the gallbladder, extrahepatic bile ducts and ampulla of Vater than previously. These lesions are discussed in detail and profusely illustrated. Likewise, lesions that closely simulate malignant neoplasms are also described and illustrated. Also included are the giant cell neoplasms and the gastrointestinal stromal tumors as well as the new subtypes of carcinomas such as large cell neuroendocrine carcinomas and adenocarcinomas with pyloric gland or foveolar phenotype. The role of immunohistochemistry in the diagnosis of a wide variety of neoplasms is emphasized, as well.
Normal Anatomy and Embryology * Histologic Classification * Benign Epithelial Tumors of the Gallbladder * Dysplasia/ Carcinoma in Situ of the Gallbladder * Carcinoma of the Gallbladder * Endocrine Tumors and Tumors of Paraganglia * Benign and Malignant Mesenchymal Nonepithelial and Neurogenic Tumors * Secondary Tumors of the Gallbladder * Hyperplastic Metaplastic and Tumor-like Lesions of the Gallbladder * Benign Epithelial Tumors and Biliary Papillomatosis of the Extrahepatic Bile Ducts * Carcinoma of the Extrahepatic Bile Ducts * Dysplasia Carcinoma in Situ and Invasive Carcinoma of the Extrahepatic Bile Ducts * Endocrine and Benign Mesenchymal Tumors of the Extrahepatic Bile Ducts * Malignant Mesenchymal and Miscellaneous Tumors of the Extrahepatic Bile Ducts * Secondary Tumors of the Extrahepatic Bile Ducts * Metaplastic and Tumor-like Lesions of Extrahepatic Bile Ducts * Primary Sclerosing Cholangitis * Preinvasive Neoplastic Lesions of the Vaterian System * Malignant Epithelial Tumors of the Vaterian System * Neuroendocrine Tumors and Related Neoplasms of the Vaterian System * Tumor and Tumor-like Lesions of the Minor Papilla * Benign and Malignant Mesenchymal Tumors and Other Malignant Tumors of the Vaterian System * Tumor-like Lesions of the Vaterian System * Secondary Tumors of the Vaterian System * Prosection of the Pancreatoduodenectomy Specimen
Jorge Albores-Saavedra, Chairman, Dept of Pathology, Medica Sur Clinic and Foundation, Professor of Oncologic Pathology, National Autonomous University of Mexico School of Medicine, Mexico City, Mexico; Donald Earl Henson and David S Klimstra