The Global Burden of Chlamydiae. Chlamydiae, Genomics and Global Public Health

By Deborah Dean (University of California at Berkeley, USA & University of California at San Francisco, USA)

This book describes the major discoveries regarding chlamydial evolution, virulence, and pathogenesis as they relate to human chlamydialdiseases worldwide. It discusses these discoveries through the application of new and advanced bioinformatics and statistical tools for comparative genomics, microarray analyses, and functional genomics. This monograph also deals with the threat posed by the ex9788496344334panding and evolving repertoire of chlamydial organisms that originate from reptiles and lower-vertebrate mammals, as well as from the environment. It includes an in-depth discussion on how these research discoveries help to bring about approaches for global disease interventions including vaccine development, and on the broader public health impact. This book will appeal to those interested in infectious diseases generally.

Contents:

• Introduction to Chlamydial Taxonomy and Nomenclature
• Introduction to Chlamydial Genomes and Expression Microarrays
• How Data are Generated
• Bioinformatics and Statistical Approaches to Data Analyses
• Discoveries Related to Chlamydia Trachomatis: Impact on Our Understanding of Tissue Tropism, Virulence and Disease Pathogenesis and Implications for Global Disease Control
• Discoveries Related to Environmental and Non-human Chlamydiae and How These May Influence Our Understanding of this Pathogen and Impact Human Disease

Readership: Researchers and public health practitioners interested in infectious diseases and the application of bioinformatics tools.