Sepsis

About this book

• Offers new, effective strategies to prevent and treat sepsis
• Examines how the pathways implicated in early and late sepsis interact
• Describes numerous tested-and-proven pharmacological approaches to provide state-of-the-technology care for patients in early and late sepsis
• Draws on the expertise of a multi-disciplinary team of medical experts

Sepsis is a multi-factorial disease process and this volume provides comprehensive and in-depth reviews of both the basic science and more practical aspects of patient management. These include detailed information on the epidemiology and genetics of sepsis as well as the metabolic and cardiovascular responses to infection. Infectious disease, in relation to sepsis, is well covered including chapters on unusual/exotic infections, control of infection and the rational use of antibiotics. Haematological aspects of sepsis are also reviewed in detail. Further chapters focus on the currently controversial areas of clinical trial design in sepsis and protocol-driven care. A specific chapter, with illustrated cases, draws practical lessons and offers useful management "tips".

The patient with sepsis provides a major challenge to the hospital acute team and septic shock is the commonest cause of admission to General Critical Care Units in the industrialised world. The incidence of sepsis is also increasing, in part due to the more complex patient case mix which is a feature of modern hospital practice.

This volume will be useful to both trainees in Critical Care and Anaesthesia as well as Infectious Disease and General Medical trainees. It also provides qualified practitioners in these fields with a comprehensive resource on sepsis-related topics.

Written for:

• Doctors, specialists, surgeons, critical care nurses, allied health professionals

Keywords:

• Care
• Cbcc
• Critical
• Lumley
• Sepsis

Contents

• Contributors
• Chapter 1 Sepsis: Introduction and Epidemiology
  Simon V. Baudouin
• Chapter 2 Mechanisms of Innate Immunity in Sepsis
  Stuart F.W. Kendrick and David E.J. Jones
• Chapter 3 Metabolic and Endocrine Changes in Sepsis and the Catabolic State
  Steven G. Ball
• Chapter 4 Hematological and Coagulation Changes in Sepsis
  Tina T. Biss and J. Wallace-Jonathan
• Chapter 5 The Genetics of Sepsis and Infl ammation
  Martin F. Clark
• Chapter 6 Cardiac, Circulatory, and Microvascular Changes in Sepsis and Multiorgan Dysfunction Syndrome
  Chris Snowden and Joseph Cosgrove
• Chapter 7 Specifi c Bacterial Infections in the Immunocompetent Patient
  Hamad A. Hadi and D. Ashley Price
• Chapter 8 Infection in the Immunocompromised Patient
  Michael H. Snow and Nikhil Premchand
• Chapter 9 Severe Infections in the Returning Traveler
  Jacob P. Wembri and Matthias L. Schmid
• Chapter 10 Antibiotic Prescribing Including Antibiotic Resistance
  Debbie Wearmouth and Steven J. Pedler
• Chapter 11 Infection Control in the Intensive Care Unit
  David Tate and Steven J. Pedler
• Chapter 12 Randomized Controlled Trials in Sepsis
  Helen J. Curtis and Anna Harmar
• Chapter 13 Guidelines, Protocols, and the Surviving Sepsis Guidelines: A Critical Appraisal
  Ian Nesbitt
• Chapter 14 Practical Approaches to the Patient with Severe Sepsis: Illustrative Case Histories
  Victoria Robson
• Index