About this book
Vascular disease provides a clear example of the inherent and practical relationship between basic science and clinical medicine. Basic science underpins the rationale of treatment and potential future therapeutic approaches; problems in clinical management often direct new lines of laboratory research. Progress in treatment cannot continue without this close collaboration and this book has been designed to review this fascinating collaborative field of medical science.
As part of this evolving collaboration, Vascular Complications of Human Disease: Mechanisms and Consequences reviews the study, pathogenesis, management and treatment of some of the most common vascular diseases. The book includes discussions of approaches to gene therapy and aspects of regenerative medicine plus also physiology and pathogenesis, surgical and pharmacologic treatment, and complications.
Clinical specialists caring for patients with any form of vascular disease must clearly understand the basic scientific rationale for disease pathogenesis. This book presents a cohesive review of our current understanding of the most important areas of clinical science and medicine in vascular disease and identifies areas for research in the future. It will be a useful reference for basic and clinical scientists, and clinical specialists in vascular surgery, cardiology, angiology, neurology and any discipline in which the vascular system plays a fundamental part in the disease process.
Written for: The readership is international and diverse.
Essential reading and reference for clinicians and basic scientists in all
fields of medicine, because there are vascular components to many diseases in
different organ systems.
Foreword by Dame Carol Black, Lewis J. Rubin, and Jeremy D. Pearson
Section One Treatments for Pulmonary Vascular Disease
1 Therapy for Pulmonary Vascular Disease: Past, Present, and Future
Lewis J. Rubin
2 Nitric Oxide Axis in Cardiopulmonary Disease
3 Endothelin Signaling in the Cardiomyocyte
Peter H. Sugden and Angela Clerk
4 TGF-ß/BMP Signaling in Pulmonary Vascular Disease
Rachel J. Davies and Nicholas W. Morrell
Section Two Model Systems
5 Endothelin System in Chronic Kidney Disease
Neeraj Dhaun, David J. Webb, and Jane Goddard
6 Endothelial Activation in Infl ammation: Lessons Learned from E-Selectin
Dorian O. Haskard
7 Pathogenic Mediators of Vessel Sclerosis: Regulation of
Vascular Smooth Muscle Cell Proliferation by Growth Factors, the Extracellular Matrix, and the Endothelium
Mark Bond, Yih-Jer Wu, Graciela Sala-Newby, and Andrew C. Newby
8 Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins
Kristofer Rubin, Åsa Lidén, Tijs van Wieringen, and Rolf K. Reed
Section Three Vascular Complications
9 Vascular Complications of Systemic Sclerosis: A Molecular Perspective
Daryll M. Baker and Christopher Denton
10 Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury
Susanna Tomasoni and Ariela Benigni
Section Four Surgical Approaches
11 Current State of Medical Therapies for Peripheral Vascular Disease
Janice C.S. Tsui and Daryll M. Baker
12 Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the “No-Touch” Technique
Domingos Sávio Ramos de Souza and Bruno Botelho Pinheiro
13 Toward the Prevention of Vein Graft Failure . . . . . . . . . . . . . . . . . . . 158
Jamie Y. Jeremy, Sarah J. George, Nilima Shukla, Marcella Wyatt, Jonathon Bloor, Andrew C. Newby, and Gianni D. Angelini
Section Five Genetics, Gene Therapy, and Tissue Engineering
14 Statins and Cholesterol: How Low Can You Go?
Dimitri P. Mikhailidis
15 Endothelin-1–Promoting Actions in the Growth and Angiogenesis of Solid Cancers
16 Gene Therapy for Apolipoprotein A-I and HDL—The Ultimate Treatment for Atherosclerosis
Petra Disterer, Eyman Osman, and James S. Owen
17 ETS Family of Transcription Factors and the Vascular System
18 Aortic Valve: From Function to Tissue Engineering
Adrian H. Chester, Najma Latif, Magdi H. Yacoub, and Patricia M. Taylor