Stem Cell and Gene-Based Therapy

About this book

Regenerative medicine - stem cell and gene-based therapy - provides a new clinical approach for restoring function of damaged organs and tissues. There has been incredible progress in experimental strategies for tissue regeneration, particularly in cell transplantation and stem cell research. These have led to potential treatment options for many otherwise fatal conditions, including end-stage organ failure. Cell therapy and tissue engineering of viable grafts could therefore provide prospective new solutions to the serious problems of organ donor shortage.

Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine is written by the leading figures in the field of stem cells, gene therapy and tissue engineering and covers the major approaches to regenerative medicine, ensuring that techniques learnt in one discipline are disseminated across other areas of medicine. This allows practitioners to gain knowledge not only of how regenerative medicine applies to their own discipline directly but also how it will benefit their patients in the years to come. Consequently, the multidisciplinary nature of the book appeals to students, scientists and clinicians from a wide spectrum of disciplines, including cardiology, pulmonology, neurology, ophthalmology, orthopedics, and dermatology.

Written for:

Internal medicine clinicians (residents through to Fellows), dermatologists, ophthalmologists, researchers in stem cell medicine, cardiologists, neurologists

Keywords:

• Cardiac regeneration
• Ethics
• Gene therapy
• Parkinson disease therapy
• Regenerative medicine
• Skin regeneration
• Stem cell
• Stem cell transplantation
• Wound healing

Table of contents

Heart: Introduction.- Renovation of the Injured Heart with Myocardial Tissue Engineering.- Adult Stem Cells for Myocardial Tissue Repair.- Regeneration of the Functional Myocardium Using Human Embryonic Stem Cells.- Therapeutic Angiogenesis.- Cell Therapy for Heart Failure.- Neuro: Introduction.- Cell Transplantation for Diseases of Myelin.- Stem Cells as a Source for Cell Replacement in Parkinson’s Disease.- Cell Replacement Therapy in Acute Stroke: Current State.- Gene Therapy to the Nervous System.- Musculoskeletal: Introduction.- Mesenchymal Stem Cells: Where Can You Find Them? How Can You Use Them?- Basic to Clinical Cartilage Engineering, Past, Present and Future Discussions.- Cartilage.- Bone Regeneration.- Osteoarthritis and Mesenchymal Cells – The Prospects for Repair of the Disease by Cell Transplantation and Tissue Engineering.- Kidney.- Introduction.- Progenitor Cell Therapy for Kidney Regeneration.- Tissue Engineering: The Bladder.- Eye.- Introduction.- Neuroprotection in Ophthalmology: A Review.- Autoimmunity for CNS Maintenance, Regeneration and Renewal: Development of a T Cell-Based Vaccination Against Neurodegeneration.- Retinal Repair by Stem Cell Transplantation.- Induction of Ocular Surface Regeneration.- Pancreas.- Introduction.- Insulin-Producing Cells Generated from Non-Pancreatic Tissues Islets from Pancreatic Progenitor Cells (Duct, Islet, and Exocrine).- Generation of Islets from Pancreatic Progenitor Cells.- Embryonic Stem Cells as a Source of Pancreatic Precursors and Islet Cells in Vitro.- Hematology.- Introduction.- Human Umbilical Cord Blood Transplantation: A viable Option for Stem Cell Graft.- Nonmyeloablative Stem-Cell Transplantation in the Treatment of Hematological Malignancies.- Haematopoietic Stem Cell Transplantation from HLA Haploidentical Donor.- Skin.- Introduction.- Wound Healing and Skin Substitutes.- Skin Regeneration From Multipotent Adult and Embryonic Stem Cells.