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Bone and Osteoartthritis. Vol 4
Bronner, F.
1ª Edición Noviembre 2007
Inglés
Tapa dura
215 pags
1200 gr
19 x 27 x 2 cm
ISBN 9781846285134
Editorial SPRINGER
LIBRO IMPRESO
-5%
343,19 €326,03 €IVA incluido
329,99 €313,49 €IVA no incluido
Recíbelo en un plazo de
2 - 3 semanas
Bone and Osteoarthritis places emphasis on the molecular and cellular events
that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes
this from other books on the disease.
A novel aspect is the attention given to the possible epigenetic basis, together
with a discussion of the genetics predisposing to osteoarthritis.
Detailed analyses are given of the role of the synovium, of the molecular mechanisms
that lead to degradation of the cartilage matrix, of the hypertrophy of the
cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to
novel approaches to clinical treatment, utilizing anabolic mediators or molecules
that target steps in the disease process. Also discussed are animal models and
how mechano-responsiveness is compromised by mechanical injury.
Orthopedics and rheumatology have become close conceptually, as advances in
bone and joint biology have enabled bench and translational scientists, as well
as practitioners, to approach clinical problems comprehensively. Because bone
plays a role in initiating osteoarthritis, therapeutic approaches focusing on
bone tissue are included in the discussion of novel treatments. The general
topic of osteoarthritis is therefore a timely subject for a series on bone biology.
This book, intended for clinicians, researchers and students, provides information
that will orient the novice and update the specialist. No other book treats
the relationship of bone to osteoarthritis in similar fashion or provides a
comparable underpinning of joint pathophysiology.
Written for:
Students, researchers and clinicians
Keywords:
"Topics in Bone
Table of contents
Overview chapter on the pathogenesis of OA - The role of bone in the development of OA - Bone derived factors (cytokines and growth factors) and their influence on cartilage - The role of the synovium in OA - The cartilage-bone interface in OA/calcified cartilage zone - Cartilage matrix destruction: MMPs and TIMPs - Anabolic mediators of cartilage healing - Role of chondrocyte hypertrophy in OA - The genetics of OA - Animal Models of OA - Biomechanical Factors in OA - Treatment: Novel Pharmaceuticals.
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