Neurology and Pregnancy. Clinical Management

Overview

Pregnancy complicated by neurological disorders is a challenging area for both Obstetricians and Neurologists. Treatment of the maternal condition often needs to be adjusted because of concerns for the fetus, and some conditions will have a major impact on the method, mode and timing of delivery. Many of the clinical problems that arise in pregnant women with neurological disease have not been the subject of clinical trials, so management must often be based on what published evidence is available and a good understanding of the likely interactions between the condition and pregnancy and vice versa.

The editors and contributors represent a team with considerable experience in this area. They offer their ‘best practice’ advice as how to treat the mother effectively, ensuring fetal safety, as well as embracing a philosophy that the pregnancy of a woman with neurological disease should be made as enjoyable and rewarding for her as is possible.

Contents

• Foreword - Catherine Nelson-Piercy Foreword – Nigel Leigh
• List of contributors
• Preface

Part I General Issues

• 1. Neurogenetics and pregnancy - Dragana Josifova
• 2. Imaging during pregnancy - Francessa Wilson and Jozef Jarosz
• 3. Intra-uterine imaging, diagnosis, and intervention in neurological disease - William Dennes
• 4. Disposition of drugs in pregnancy: anti-epileptic drugs - David Berry
• 5. Therapeutics and breastfeeding - Thomas W Hale
• 6A. Neuro-anaesthesia in pregnancy - James Arden
• 6B. Neurocritical care for the pregnant woman - Clemens Pahl
• 6C. Neurovascular intervention during pregnancy: cerebral aneurysms and vascular malformations - Daniel Walsh
• 7. Analgesia and anaesthesia in neurological disease and pregnancy - Jayaram Dasan
• 8. Psychiatric and neuropsychiatric disorders in pregnancy and the postpartum period - John Moriarty and Gertrude Seneviratne
• 9. Ethical and legal issues - Peter Haughton and Hannah Turton

Part II Neurological Disease

• 10. Eclampsia / pre-eclampsia and peripartum convulsions - Michael S Marsh
• 11. Blackouts arising in pregnancy - Robert Delamont and Nicholas Gall
• 12. Epilepsy and pregnancy - Lina AM Nashef, Nicholas Moran, Sara Lailey, and Mark P Richardson
• 13. Headache in pregnancy - Anish Bahra
• 14. Infections in pregnancy - Iskandar Azwa, Michael S Marsh, and David A Hawkins
• 15. Idiopathic intracranial hypertension - Paul Riordan-Eva
• 16. Stroke in pregnancy - Victoria Mifsud
• 17. Vascular malformations of the brain in pregnancy - David P Breen, Catharina JM Klijn, and Rustam Al-Shahi Salman
• 18. Pituitary disease in pregnancy - Dorota Dworakowska and Simon Aylwin
• 19. Neuro-oncology in pregnancy - Fiona Harris, Sarah Jefferies, Rajesh Jena, Katherine Burton, Lorraine Muffett, and Neil Burnet
• 20. Movement disorders in pregnancy - Yogini Naidu, Prashanth Reddy, and K Ray Chaudhuri
• 21. Multiple Sclerosis - Peter A Brex and Pauline Shaw
• 22. Nutritional deficiencies in pregnancy - Roy A Sherwood
• 23. Spinal disease and pregnancy - Matthew Crocker and Nicholas Thomas
• 24. Neurological disability and pregnancy - David Rushton
• 25. Peripheral nerve diseases - Robert DM Hadden
• 26. Muscle disease and myasthenia in pregnancy - Fiona Norwood

• Appendix: Useful websites
• Index

Author

Michael Marsh, FRCOG, MD, Department of Obstetrics and Gynaecology, King’s College Hospital London, UK
Lina Nashef, FRCP, MD, MBChB, Department of Neurology, King’s College Hospital London, UK
Peter Brex, MRCP, Department of Neurology, King’s College Hospital London, UK