• information on the cost-effectiveness of the various types of opioid
• pharmacotherapies used for the management of opioid dependence
• knowledge from international research literature on the value and relative efficacy of the various pharmacological approaches
This guide includes pharmacotherapies used in the management of withdrawal from opioids such as clonidine, lofexidine, methadone, buprenorphine and naltrexone and also symptomatic medications. It also includes different forms of maintenance therapy using opioid agonists such as methadone, LAAM, buprenorphine, slow-release oral morphine and diamorphine, and opioid antagonists such as naltrexone.