ICD-10-CM 2025: The Complete Official Codebook (ICD-10-CM the Complete Official Codebook)

How to Use ICD-10-CM: The Complete Official Codebook 2025
Introduction
What’s New for 2025
Conversion Table
10 Steps to Correct Coding
Official ICD-10-CM Guidelines for Coding and Reporting
Indexes
Index to Diseases and Injuries
Neoplasm Table
Table of Drugs and Chemicals
External Causes Index
Index Notations
Tabular List of Diseases
Code and Code Descriptions
Tabular Notations
Official Notations
Publisher Notations
Icons
Color Bars
Chapter-Level Notations
Appendixes
Illustrations
What’s New for 2025
Official Updates
Proprietary Updates
Conversion Table of ICD-10-CM Codes
10 Steps to Correct Coding
ICD-10-CM Official Guidelines for Coding and Reporting
ICD-10-CM Index to Diseases and Injuries
ICD-10-CM Neoplasm Table
ICD-10-CM Table of Drugs and Chemicals
ICD-10-CM Index to External Causes
ICD-10-CM Tabular List of Diseases and Injuries
Chapter 1: Certain Infectious and Parasitic Diseases (A00–B99), U07.1, U09.9
Chapter 2: Neoplasms (C00–D49)
Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50–D89)
Chapter 4: Endocrine, Nutritional, and Metabolic Diseases (E00–E89)
Chapter 5: Mental, Behavioral, and Neurodevelopmental Disorders (F01–F99)
Chapter 6: Diseases of the Nervous System (G00–G99)
Chapter 7: Diseases of the Eye and Adnexa (H00–H59)
Chapter 8: Diseases of the Ear and Mastoid Process (H60–H95)
Chapter 9: Diseases of the Circulatory System (I00–I99)
Chapter 10: Diseases of the Respiratory System (J00–J99), U07.0
Chapter 11: Diseases of the Digestive System (K00–K95)
Chapter 12: Diseases of the Skin and Subcutaneous Tissue (L00–L99)
Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00–M99)
Chapter 14: Diseases of Genitourinary System (N00–N99)
Chapter 15: Pregnancy, Childbirth, and the Puerperium (O00–O9A)
Chapter 16: Certain Conditions Originating in the Perinatal Period (P00–P96)
Chapter 17: Congenital Malformations, Deformations, and Chromosomal Abnormalities (Q00–Q99)
Chapter 18: Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00–R99)
Chapter 19: Injury, Poisoning, and Certain Other Consequences of External Causes (S00–T88)
Chapter 20: External Causes of Morbidity (V00–Y99)
Chapter 21: Factors Influencing Health Status and Contact with Health Services (Z00–Z99)
Chapter 22: Codes for Special Purposes (U00–U85)
Appendixes
Appendix A: Valid 3-character ICD-10-CM Codes
Appendix B: Pharmacology List 2025
Appendix C: Z Codes for Long-Term Drug Use with Associated Drugs
Appendix D: Z Codes Only as Principal/First-Listed Diagnosis
Appendix E: Centers for Medicare & Medicaid Services Hierarchical Condition Categories (CMS-HCC)
Appendix F: Centers for Medicare & Medicaid Services Quality Payment Program
Illustrations
Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50–D89)
Red Blood Cells
White Blood Cell
Platelet
Coagulation
Spleen Anatomical Location and External Structures
Spleen Interior Structures
Chapter 4: Endocrine, Nutritional, and Metabolic Diseases (E00–E89)
Endocrine System
Thyroid
Thyroid and Parathyroid Glands
Pancreas
Anatomy of the Adrenal Gland
Structure of an Ovary
Testis and Associated Structures
Thymus
Chapter 6: Diseases of the Nervous System (G00–G99)
Brain
Cranial Nerves
Peripheral Nervous System
Spinal Cord and Spinal Nerves
Nerve Cell
Trigeminal and Facial Nerve Branches
Chapter 7: Diseases of the Eye and Adnexa (H00–H59)
Eye
Posterior Pole of Globe/Flow of Aqueous Humor
Lacrimal System
Eye Musculature
Eyelid Structures
Chapter 8: Diseases of the Ear and Mastoid Process (H60–H95)
Ear Anatomy
Chapter 9: Diseases of the Circulatory System (I00–I99)
Anatomy of the Heart
Heart Cross Section
Heart Valves
Heart Conduction System
Coronary Arteries
Arteries
Veins
Internal Carotid and Vertebral Arteries and Branches
External Carotid Artery and Branches
Branches of Abdominal Aorta
Portal Venous Circulation
Lymphatic System
Axillary Lymph Nodes
Lymphatic System of Head and Neck
Lymphatic Capillaries
Lymphatic Drainage
Chapter 10: Diseases of the Respiratory System (J00–J99), U07.0
Respiratory System
Upper Respiratory System
Lower Respiratory System
Paranasal Sinuses
Lung Segments
Alveoli
Chapter 11: Diseases of the Digestive System (K00–K95)
Digestive System
Omentum and Mesentery
Peritoneum and Retroperitoneum
Chapter 12: Diseases of the Skin and Subcutaneous Tissue (L00–L99)
Nail Anatomy
Skin and Subcutaneous Tissue
Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00–M99)
Bones and Joints
Shoulder Anterior View
Shoulder Posterior View
Elbow Anterior View
Elbow Posterior View
Hand
Hip Anterior View
Hip Posterior View
Knee Anterior View
Knee Posterior View
Foot
Muscles
Chapter 14: Diseases of Genitourinary System (N00–N99)
Urinary System
Male Genitourinary System
Female Internal Genitalia
Female Genitourinary Tract Lateral View
Chapter 15: Pregnancy, Childbirth, and the Puerperium (O00–O9A)
Term Pregnancy – Single Gestation
Twin Gestation–Dichorionic–Diamniotic (DI-DI)
Twin Gestation–Monochorionic–Diamniotic (MO-DI)
Twin Gestation–Monochorionic–Monoamniotic (MO-MO)
Chapter 19: Injury, Poisoning, and Certain Other Consequences of External Causes (S00–T88)
Types of Fractures
Salter-Harris Fracture Types

ICD-10-CM 2025: The Complete Official Codebook includes official guidelines, provides the entire updated code set for diagnostic coding, organized to make the challenge of accurate coding easier. This codebook is the cornerstone for establishing medical necessity, correct documentation, determining coverage and ensuring appropriate reimbursement.   Each of the 22 chapters in the Tabular List of Diseases and Injuries is organized to provide quick and simple navigation to facilitate accurate coding. The book also contains supplementary appendixes including a coding tutorial, pharmacology listings, a list of valid three-character codes and additional information on Z-codes for long-term drug use and Z-codes that can only be used as a principal diagnosis.   FEATURES AND BENEFITS Full list of code changes. Quickly see the complete list of new, revised, and deleted codes affecting the CY2025 codes, including a conversion table and code changes by specialty. QPP symbol in the tabular section. The symbol identifies diagnosis codes associated with Quality Payment Program (QPP) measures under MACRA. New and updated coding tips. Obtain insight into coding for physician and outpatient settings. Chapter 22 features U-codes and coronavirus disease 2019 (COVID-19) codes. Improved icon placement for ease of use. New and updated definitions in the tabular listing. Assign codes with confidence based on illustrations and definitions designed to highlight key components of the disease process or injury and provide better understanding of complex diagnostic terms. Intuitive features and format. Includes color illustrations and visual alerts, including color-coding and symbols that identify coding notes and instructions, additional character requirements, codes associated with CMS hierarchical condition categories (HCC), Medicare Code Edits (MCEs), manifestation codes, other specified codes, and unspecified codes. Placeholder X. This icon alerts the coder to an important ICD-10-CM convention—the use of a “placeholder X” for three-, four- and five-character codes requiring a seventh-character extension. Coding guideline explanations and examples. Detailed explanations and examples related to the application of the ICD-10-CM chapter guidelines are provided at the beginning of each chapter in the tabular section. Muscle/tendon translation table. This table is used to determine muscle/tendon action (flexor, extensor, other), which is a component of codes for acquired conditions and injuries affecting the muscles and tendons. Index to Diseases and Injuries. Provides a quick way to search for diseases and injuries codes in the 22 chapters of the Tabular List of Diseases and Injuries. Appendices. Supplement your coding knowledge with information on proper coding practices, risk-adjustment coding, pharmacology, and Z-codes.