Cerebrospinal Fluid: Clinical Biochemistry, Physiology and Diagnostic Characteristics

Description

The cerebrospinal fluid (CSF) is a dynamic, metabolically active fluid that occupies the subarachnoid space and the ventricular system around the brain, and has many important functions. CSF is a promising body fluid for the search of biomarkers associated with neurological disease, because the CSF has more physical contact with brain than any other fluids, biochemical changes related to many pathology may be reflected in the CSF. Although CSF is obtained by lumbar puncture, invasive and potentially painful for the patient, it is probably the most informative fluid in biomarkers discovery for neurological disease prognosis. This book discusses CSF biomarkers; novel developed biomarkers in neurological diseases; CSF biochemical markers of cerebral metabolism in dogs; and guidance for the selection and interpretation of laboratory tests. (Imprint: Nova Biomedical)

Contents

Preface pp.vii-x

CSF Biomarkers: Review of the Literature and Critical Appraisal in Spinal Cord Injury
(Tristan Fried, George M. Ghobrial, James S. Harrop, Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA, and others)pp.1-14

Cerebrospinal Fluid: Novel Developed Biomarkers in Neurological Disease
(M. Dessi, F. Duranti, M. Pieri, G. Sancesario, R. Zenobi, S. Bernardini, Department of Experimental Medicine and Surgery, “Tor Vergata” University Hospital, Rome, Italy)pp.15-60

Cerebrospinal Fluid Biochemical Markers of Cerebral Metabolism in Dogs
(Alba Galán, Beatrice E. Carletti, Campus Universitario Rabanales, Department of Animal Medicine and Surgery, Córdoba, Spain)pp.61-74

Cerebrospinal Fluid: Guidance for the Selection and Interpretation of Laboratory Tests
(Karina Rodríguez-Capote, Vilte E. Barakauskas, Mathew P. Estey, Trefor N. Higgins, DynaLIFEDX Diagnostic Laboratory Services and
The Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada)pp.75-106

Index pp.107-116