Motor Neuron Diseases: Causes, Classification and Treatments

Description

Motor neuron disease (MND), also commonly known as amyotrophic lateral sclerosis (ALS), is a chronic neurodegenerative disorder of the motor system in adults, characterized by the loss of motor neurons in the cortex, brain stem and spinal cord. This book presents current research from across the globe in the study of the causes, classification and treatments of MND, including membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS; motorneuron specific calcium dysregulation and perturbed cellular calcium homeostasis in ALS; stem cells and their application in ALS treatment; excitotoxicity and selective motor neuron degeneration and therapeutic invervention and assistive technology treatments. (Imprint: Nova Biomedical)

Contents

Chapter 1 - Motor Neuron Disease: Causes, Classification and Treatments (pp.13-50)
Authors / Editors: (Louisa Ng, Fary Khan, Neurological Rehabilitation Physician, Royal Melbourne Hospital, Poplar Road, Parkville, Melbourne, VIC, Australia)

Chapter 2 - Membrane Trafficking Defects as Determinants of Motor Neuron Susceptibility and Degeneration in ALS (pp.51-86)
Authors / Editors: (Bradley J. Turner, Julie D. Atkin, Florey Neuroscience Institutes and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, Australia, and others)

Chapter 3 - Motoneuron Specific Calcium Dysregulation and Perturbed Cellular Calcium Homestasis in Amyotrophic Lateral Sclerosis: Recent Advances Gained from Genetically Modified Animals and Cell Culture Models (pp.87-114)
Authors / Editors: (Manoj Kumar Jaiswal, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, and others)

Chapter 4 - Treatment of ALS Utilizing a Stem Cell Strategy (pp.115-136)
Authors / Editors: (Xiufang Guo, James J. Hickman, Hybrid Systems Laboratory, NanoScience Technology Center, University of Central Florida, Orlando, Florida, USA, and others)

Chapter 5 - TDP-43-Immunoreactive Pathology in Frontotemporal Lobar Degeneration with TDP Proteinopathy (FTLD-TDP) with and without Associated Motor Neuron Disease (MND) (pp.137-156)
Authors / Editors: (R.A. Armstrong, Vision Sciences, Aston University, Birmingham, United Kingdom)

Chapter 6 - Excitotoxicity and Selective Motor Neuron Degeneration (pp.157-170)
Authors / Editors: (K.A. Staats, L. Van Den Bosch, Department of Neurobiology, K.U. Leuven, Belgium, and others)

Chapter 7 - Stem Cell Application in Amyotrophic Lateral Sclerosis: Growth Factor Delivery and Cell Therapy (pp.171-182)
Authors / Editors: (Ksenija Bernau, Michael G. Meyer, Masatoshi Suzuki, Deparment of Biomedical Engineering, and Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA, and others)

Chapter 8 - Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy (SBMA) (pp.183-196)
Authors / Editors: (Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Gen Sobue, Department of Neurology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan, and others)

Chapter 9 - Expert Commentary: Motor Neuron Disease: Assistive Technology (pp.197-202)
Authors / Editors: (Louisa Ng, Fary Khan, Neurological Rehabilitation Physician, Royal Melbourne Hospital, Poplar Road, Parkville, Melbourne VIC, Australia)

Chapter 10 - Comparative Study on Application of Invasive and Non-Invasive Ventilation to ALS Patients in Japan, the USA and Europe (pp.203-222)
Authors / Editors: (Rika Yamauchi, Jun Kawamata, Shun Shimohama, Department of Neurology, School of Medicine, Sapporo Medical University, Japan)

Chapter 11 - Motor Speech Disorder in Patients with Motor Neuron Disease: How to Estimate and Manage their Disturbed Speech Sounds Clinically (pp.223-230)
Authors / Editors: (Hideto Saigusa, Department of Otolaryngology, Nippon Medical School, Tokyo, Japan)