This book offers updates on the full range of contemporary GnRH knowledge, as articulated by authoritative contributors with extensive neurophysiology experience. In this new comprehensive volume, internationally-renowned experts explain what GnRH is, describe how it works, follow its associated pathology, and predict where future GnRH research is likely headed. These objectives are clearly developed by sixteen concise yet thorough chapters covering themes across human clinical medicine, veterinary science, marine organisms, and transitional states as observed in so-called “living fossils”, as well as invertebrate biology. The authors depict GnRH fundamentals as a starting-point for examination of more recent data in this rapidly evolving field. Although ideally suited for the senior GnRH researcher, anyone with an early, basic interest in neuroendocrinology will also find this book highly approachable. Fully illustrated, indexed and annotated, this edition is an essential item in any modern personal or institutional GnRH library collection.
Table of Contents
Structure, Function & Evolutionary Aspects of Invertebrate GnRH & their Receptors; Reproductive Neuroanatomy & GnRH in the Primitive Vertebrate Order Myxiniformes (Hagfish Spp.); Dynamics of Three GnRH Forms in the Multiple Spawning Perciform Fish, Chub Mackerel, (Scomber japonicas) & Bambooleaf Wrasse (Pseudolabrus sieboldi); Physiological Perspectives of GnRH in a Poultry & Farm Animal Context; Avian GnRH: Production, Structure & Function; Contraceptive Applications of GnRH-Analogs & Vaccines for Wildlife Mammals of Southern Africa: Current Experience & Future Challenges; Slow Release GnRH Agonist Implants for Males in Companion Animal Medicine; Specific Regulation of Gonadotropin LHß- & FSHß-Subunit Gene Expression by Pulsatile GnRH Stimulation; GnRH as a Local Mediator of Developmental & Physiological Processes in Mammalian Testis; Anti-GnRH Receptor Monoclonal Antibodies as Bioequivalent Analogs of GnRH; Morphological Evidence for Involvement of Microglia in the Regulation of GnRH Neurons by Prostaglandins; Gonadotropin Releasing Hormone Analogues in Assisted Conception; GnRH-Agonist & Antagonist Protocols in Clinical IVF Practice: Patient Preference Comparisons Based on Cost & Number of Daily Injections; GnRH Functions in Regulating Cell Proliferation & Migration: Mode of Action in Extra-Pituitary Organs; Inhibitory Effects of GnRH Receptor during Cell Invasion in the Breast Cancer Cell Line MDA-MB-231; GnRH-Based Drug Targeting: Cell Adhesion & Migration Modulator Effects of GnRH Derivatives in Tumor Cells; Index.