In this book, the authors discuss the genetics, geographic variation and disorders associated with skin pigmentation. Topics include the melanocortin-1 receptor as a key melanoma risk determinant and a critical regulator of the UV DNA damage repair response; three major signalling pathways involved in the establishment of mammalian skin and hair coloration via the regulation of tyrosinase activity; multiple genes and diverse hierarchical pathways that affect human pigmentation; acquired skin pigmenation; the pro-opiomelanocortin (POMC) and melanocortin systems in the regulation of human skin pigmentation; and an overview on the melanocyte precursor migration from neural crest.
Table of Contents
Preface; The Melanocortin-1 Receptor: A Key Melanoma Risk Determinant & a Critical Regulator of the UV DNA Damage Repair Response; MC1R. EDNRB, & Kit Signaling in Pigment Regulation & Related Disorders; Multiple Genes & Diverse Hierarchical Pathways Affect Human Pigmentation; Acquired Skin Pigmentation; The Pro-Opiomelanocortin (POMC) & Melanocortin System in Regulation of Human Skin Pigmentation; Overview on the Melanocyte Precursor Migration from Neural Crest; Index.