This book provides an overview of the scientific methods used to search, analyse, appraise and synthesise studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoural and non-tumoural disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called “translational medicine”. Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease.
Table of Contents
Angiogenesis: Something Old, Something New; A Historical Appraisal of Angiogenesis Assays since Judah Folkman & Before...; Angiogenesis & Pulmonary Hypertension; Stem Cells & Angiogenesis in Skeletal Muscle Regeneration & Disease; Angiogenesis in Peripheral Artery Disease: An Emerging Therapy Targeting Skeletal Muscle; Angiogenesis in Thalassemia; Fibroblasts & Endothelial Cells: The Basic Angiogenic Unit; Regulating Functions of Angiogenesis in Prevention & Therapy of Gastric Ulcer; The Role of Angiogenesis in Renal Allograft; Angiogenesis & Lymphangiogenesis as Molecular Therapeutic Targets in Human Pterygium & Its Recurrences; The Role of Heparin Mimetic Peptide Nanofibers in Angiogenesis Process; Mast Cells & Angiogenesis in Tumoral & Non-Tumoral Disease; Angiogenesis in Tumor Microenvironment: Potential Approaches in Cancer Therapy; Angiogenesis in Breast Neoplasia; Targeting VEGF-Mediated Tumor Angiogenesis in Neuroblastoma; Molecular Pathways of Angiogenesis in Cervical Cancer; Index.