In this book, the biology, current treatment modalities and new emerging therapeutic approaches and targets for glioma, a highly aggressive and invasive brain tumour, are described. The pathologic features of the most frequently WHO classified gliomas encountered in clinical practice, are reviewed. Molecular genetics and specifically the mutations that underlie brain tumours are outlined as is the inherited genetic susceptibility and lifestyle risk factors reflecting on glioma epidemiology. The clinical features of glioma as well as diagnostic methods that include conventional and advanced magnetic resonance imaging (MRI) and brain mapping are also discussed with an outline of emerging treatment options.
Table of Contents
Epidemiology of Gliomas; Pathology of Gliomas; Molecular Genetics of Brain Tumors; Clinical Features of Central Nervous System Tumors; Neuro Imaging of Malignant Gliomas; Intra-operative Brain Mapping in Glioma Surgery; Preoperative Brain Mapping in Glioma Surgery; Neurological Complications of Gliomas; Radiation Therapy in the Management of Glioma; Dose Rate Modulation for Safe Delivery of Re-treatment Irradiation in Recurrent Glioma Patients; Targeted Therapies for Malignant Gliomas; Antiangiogenic Therapies for High-Grade Glioma; CSF Dissemination of Gliomas & Primary Brain Tumors; Stem Cell Biology as it Relates to Glioma Pathogenesis & Treatment; Glioma Extracellular Matrix Molecules as Therapeutic Targets; Current Immunotherapeutic Targets in Gliomas; The Significance of PTEN/AKT pathway in Glioma & its Relation to Proliferation, Adhesion & Apoptosis of Glioma Cells; The Thiol Redox System in Glioma Biology: Clinical Target & Significance in Resistance to Glioma Chemotherapy; Loco-regional & Targeted Therapy of Glioma with Chlorotoxin; Cytokine-directed Recombinant Cytotoxins for Glioma Treatment; Nanoparticle Based Delivery of Therapeutics to Glioma; Index.