No hay productos en el carrito

Targeting Cancer (Cold Spring Harbor Symposia on Quantitative Biology, Vol. 81) (Hardcover)
Lowe, S. — Polyak, K. — Stewart, D. — Stillman, B. — White, E.
1ª Edición Septiembre 2017
Inglés
Tapa dura
368 pags
1219 gr
21 x 28 x 3 cm
ISBN 9781621822097
Editorial COLD SPRING HARBOR LABORATORY
LIBRO IMPRESO
-5%
286,55 €272,22 €IVA incluido
275,53 €261,75 €IVA no incluido
Recíbelo en un plazo de
2 a 3 semanas
Decription
The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.
Contents
Symposium Participants
Foreword
Cancer Stem Cells
Normal and Neoplastic Stem Cells
Melissa N. McCracken, Benson M. George, Kevin S. Kao, Kristopher D. Marjon, Tal Raveh, and Irving L. Weissman
Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy
Diwakar R. Pattabiraman and Robert A. Weinberg
Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations
Elizabeth Allen, Rindert Missiaen, and Gabriele Bergers
Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma
Sheila R. Alcantara Llaguno, Xuanhua Xie, and Luis F. Parada
Genetics and Epigenetics
The Enigma of p53
Guillermina Lozano
Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome
Joanna Achinger-Kawecka, Phillippa C. Taberlay, and Susan J. Clark
Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
John L. Pulice and Cigall Kadoch
The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia
Jae-Seok Roe and Christopher R. Vakoc
Metabolism
Reexamining How Cancer Cells Exploit the Body's Metabolic Resources
Craig B. Thompson and Wilhelm Palm
Autophagy, Metabolism, and Cancer
Jessie Yanxiang Guo and Eileen White
A Time for MYC: Metabolism and Therapy
Chi V. Dang
Beyond the Oncogene Revolution: Four New Ways to Combat Cancer
Thorsten Berger, Mary E. Saunders, and Tak W. Mak
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer
Robert U. Svensson and Reuben J. Shaw
Targets, Vaccines, and Therapeutics
Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design
Jasreet Hundal, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichael, Adam Coffman, and Elaine R. Mardis
Targeting HIF2 in Clear Cell Renal Cell Carcinoma
Hyejin Cho and William G. Kaelin
BET Bromodomain Proteins as Cancer Therapeutic Targets
Shaokun Shu and Kornelia Polyak
To Prime, or Not to Prime: That Is the Question
Danielle S. Potter and Anthony Letai
Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer
Stefano Annunziato, Marco Barazas, Sven Rottenberg, and Jos Jonkers
Microenvironment and Metastasis
Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications
Hanqiu Zheng, Wenyang Li, and Yibin Kang
Cancer, Oxidative Stress, and Metastasis
Jennifer G. Gill, Elena Piskounova, and Sean J. Morrison
RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers
Najme Faham ?and Alana L. Welm
Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis
Madeleine J. Oudin and Valerie M. Weaver
Models of Cancer
Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets
Saori Furuta and Mina J. Bissell
Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities
Douglas T. Fearon
Modeling Breast Cancer Intertumor and Intratumour Heterogeneity Using Xenografts
Alejandra Bruna, Oscar M. Rueda, and Carlos Caldas
Challenges and Opportunities in Modeling Pancreatic Cancer
Michael E. Feigin and David A. Tuveson
Cancer Genomics and Tumor Heterogeneity
Functional Genomic Characterization of Cancer Genomes
Thomas P. Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L. Hong, Mik Rinne, Andrew J. Aguirre, ?Jesse S. Boehm, and William C. Hahn
How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually ?Exclusive Oncogenic Mutations?
Harold Varmus, Arun M. Unni, and ?William W. Lockwood
A Pipeline for Drug Target Identification and Validation
Eusebio Manchado, Chun-Hao Huang, Nilgun Tasdemir, Darjus F. Tschaharganeh, John E. Wilkinson, and Scott W. Lowe
Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity
David T. Miyamoto, David T. Ting, Mehmet Toner, Shyamala Maheswaran, and Daniel A. Haber
Discovery of Double-Stranded Genomic DNA in Circulating Exosomes
Raghu Kalluri and ?Valerie S. LeBleu
Summary
Moving Closer to Victory
Taru Muranen and Joan S. Brugge
Dorcas Cummings Lecture
Charles Sawyers
Conversations at the Symposium
Gabriele Bergers
Joan Brugge
Karen Cichowski
Susan Clark
Gerard Evan
Daniel Haber
William Kaelin
Raghu Kalluri
Scott Lowe
Guillermina (Gigi) Lozano
David Lyden
Elaine Mardis
Sean Morrison
Benjamin Neel
Luis Parada
Sir Michael Stratton
David Tuveson
Christopher Vakoc
Harold Varmus
Karen Vousden
Valerie Weaver
Robert Weinberg
Eileen White
Author Index
Subject Index
Productos relacionados
© 2025 Axón Librería S.L.
2.116.6