Immunity and Tolerance (Symposia on Quantitative Biology, Vol. 78)

Description

The 78th Symposium spans a broad range of approaches towards increased understanding of the immune system including genetics, biochemistry, molecular and cell biology, and developmental biology. Fundamental biological discoveries are balanced with applications relevant to societal wellbeing including a variety of stratagems for harnessing the immune system to treat disease. Topics addressed by the Symposium include but are not limited to:

• Stem cells and cell fate decisions
• Regulation of immune cell development
• Antigen receptor gene assembly and modification
• Signal transduction
• Regulation of lymphocyte function
• Innate immune response and inflammation
• Adaptive immunity
• Mucosal immunity
• Organ specific immunity
• Immune regulation and tolerance
• Autoimmunity and allergy
• Immunity and cancer
• Pathogen-immune system interactions
• Vaccine development
• Novel strategies to engineer/harness immunity

Contents

Symposium Participants
Foreword

Development and Antigen Receptor Gene Assembly
TET Proteins and 5-Methylcytosine Oxidation in the Immune System
Ageliki Tsagaratou and Anjana Rao
Control of Antigen Receptor Diversity through Spatial Regulation of V(D)J Recombination
Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, and Meinrad Busslinger
Establishment and Maintenance of B Cell Identity
Rudolf Grosschedl
Transcriptional Establishment of Cell-Type Identity: Dynamics and Causal Mechanisms of T-Cell Lineage Commitment
Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, and Mary A. Yui
The Epigenetics of Early Lymphocyte Development
C. Murre

Gene Regulation
Regnase-1, a Ribonuclease Involved in the Regulation of Immune Responses
Shizuo Akira
Toward an Understanding of the Gene-Specific and Global Logic of Inducible Gene Transcription
Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, and Ann-Jay Tong
Tolerization of Inflammatory Gene Expression
John J. Seeley and Sankar Ghosh
The ‘Histone Mimicry’ by Pathogens
Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, and Alexander Tarakhovsky

Development and Function of Myeloid Subsets
Myb-Independent Macrophages: A Family of Cells That Develops with Their Tissue of Residence and Is Involved in Its Homeostasis
Elisa Gomez Perdiguero and Frederic Geissmann
The Molecular Choreography of IRF4 and IRF8 with Immune System Partners
Harinder Singh, Elke Glasmacher, Abraham B. Chang, and Bryan Vander Lugt
The IRF Family Transcription Factors at the Interface of Innate and Adaptive Immune Responses
Hiroaki Ikushima, Hideo Negishi, and Tadatsugu Taniguchi

T-Cell Differentiation and Function
IL-1 b Strikingly Enhances Antigen-Driven CD4 and CD8 T-Cell Responses
S.Z. Ben-Sasson, K. Wang, J. Cohen, and W.E. Paul
A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism
Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, and Adam T. Waickman
Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45
Ying Xim Tan, Julie Zikherman, and Arthur Weiss

NK Cells and Innate Lymphoid Cells
Dissection of Signaling in Inflammation: Three Novel Inflammatory Regulators
Thorsten Berger, Mary E. Saunders, and Tak W. Mak
Tissue-Resident Natural Killer Cells
Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, and Zhigang Tian

Microbial Immunity
Immunology Taught by Human Genetics
Jean-Laurent Casanova, Laurent Abel, and Lluis Quintana-Murci
Systems Approach to Understand the Immune Response in Tuberculosis: An Iterative Process between Mouse Models and Human Disease
Anne O’Garra
The Zebrafish Guide to Tuberculosis Immunity and Treatment
Lalita Ramakrishnan
Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity
Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, and Dan R. Littman
The Promised Land of Human Immunology
Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, and Mark M. Davis

Tolerance, TREGS and Inflammasome
Transcriptional Control of Regulatory T-Cell Differentiation
Joris van der Veeken, Aaron Arvey, and Alexander Rudensky
miR-181 and Metabolic Regulation in the Immune System
Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, and Richard A. Flavell
Encoding Immunological Memory in the Initiation of B-Cell Receptor Signaling
Susan K. Pierce and Wanli Liu

Tumor Immunology and Genome Stability
Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
Koichi Araki, Ben Youngblood, and Rafi Ahmed
Immune Surveillance of Unhealthy Cells by Natural Killer Cells
Alexandre Iannello and David H. Raulet
Studying Epstein-Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice
Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, and Klaus Rajewsky

Closing Lecture
Pathogen-Sensing, Regulatory T Cells, and Responsiveness-Tuning Collectively Regulate Foreign- and Self-Antigen Mediated T-Cell Responses
William E. Paul, Joshua D. Milner, and Zvi Grossman

Author Index

Subject Index