Cytokines. Mechanisms, Functions and Abnormalities

Description:

Cells of the immune system communicate with each other, and respond to abnormal conditions by releasing soluble proteins, named cytokines. Abnormal or dangerous conditions include infection, trauma and injury, neurological disorders, and cancer. The balance between pro- and anti-inflammatory cytokines can comfort or exacerbate the symptoms in these diseases. This book focuses on counter-regulatory and the role of cytokines in different diseases. The goal is to understand contribution of cytokines in the progression of the disease as well as therapeutic potential of cytokines in the treatment of the disease by understanding cytokine counter-regulation. (Imprint: Nova Biomedical)

Table of Contents:

Preface

I. Counter-regulatory role of cytokines

Chapter 1. Interleukin-12: effector mechanisms and homeostatic counter-regulation;pp. 3-22
(Nejat K. Egilmez, School of Medicine and Biomedical Sciences, University of Buffalo, NY, USA)

II. Role of cytokines in the nervous system and neurological diseases

Chapter 2. Cytokines: sensors of the nervous system;pp. 25-49
(Mary Fafutis-Morris and Oscar Kurt Bitzer Q., Universidad de Guadalajara, Mexico and others)

Chapter 3. Role of cytokines in hypoxic periventricular white matter damage in developing brain;pp. 51-84
(Madhuvika Murugan, Eng-Ang Ling, Charanjit Kaur, Dept. of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore)

Chapter 4. Cytokine network as attractive therapeutic target for neurodegenerative diseases;pp. 85-98
(Marcella Reale,Dept. of Oncology and Experimental Medicine, University "G.d'Annunzio, Chieti-Pescara, Italy

III. Dysregulation or modulation of cytokines during trauma and injury

Chapter 5. Cytokine dysregulation and its epigenetic control in post-traumatic stress disorder;pp. 101-116
(Juhua Zhou, Yin Zhong, Prakash Nagarkatti and Mitzi Nagarkatti, School of Medicine, University of South Carolina,Columbia, USA)

Chapter 6. Cytokines, properties and role during wound healing and response to photomodulation;pp. 117-137
(Palesa R Sekhejane and Heidi Abrahamse, University of Johannesburg, Doornfontein, South Africa)

Chapter 7. Inflammatory cytokines and heart disease: their implication in paracrine effects of measenchymal stem cell therapy;pp. 139-146
(Alice Le Huu, Guangyong Chen, and Dominique Shum-Tim, McGill University Health Center, Montreal, Quebec, Canada)

Chapter 8. The role of pro-inflammatory cytokines in osteoarthritis: new therapeutic approaches using anti-cytokine therapy and NF-kB inhibitors;pp. 147-169
(Ali Mobasheri and Mehdi Shakibaei, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK and others)

IV. The role of cytokines in cancer and periodontal disease

Chapter 9. Scavenger receptor A (SRA/CD204): a multifaceted regulator of inflammatory response and immunity;pp. 173-196
(Xiaofei Yu, Daming Zuo, John R. Subjeck and Xiang-Yang Wang, VCU Institute of Melecular Medicine, Richmond Va, USA and others)

Chapter 10. Pro-inflammatory cytokines and human prostate cancer;pp. 197-213
(Gonzalo Rodrigues-Berriguete, Benito Fraile, Ricardo Paniagua, and Mar Royuela, University of Alcala, Madrid, Spain)

Chapter 11. Vascular endothelial growth factor and its receptors in multiple myeloma;pp. 215-234
(Roberto Ria, Antonia Reale and Angelo Vacca, University of Bari "Aldo Moro" Medical School, Italy)

Chapter 12. The roles of cytokines in periodontal disease;pp. 235-254
(Hiromichi Yumoto, Kauji Hirao, Takashi Matsuo, and Yoichiro Miyake, The University of Tokushima Graduate School, Japan)

Index

Editors: Masoud H. Manjili (VCU School of Medicine, Massey Cancer Center, Richmond, Va)