Cancer Metastasis Research: Pathological Insight

Description:

Electron microscopy made possible the observation of the cellular/subcellular behavior of tumor cells in metastasis. The marked progress in molecular biology has enabled the identification of the molecules involved in metastasis. Cellular diversity of metastatic tumor cells and host cells is extremely important not only in understanding the irregular metastatic behavior of malignant tumor cells but also in elucidating why such populations may display different responses to therapy. There have been advances in research showing that clinical cancer metastasis will eventually be conquered, at least in part. This is evident from the fact that pathologists are now able to report the primary site of a metastatic tumor to clinicians. Hopefully, this book will enlighten people in the medical and research field regarding new research in cancer and the interested reader as well. (Imprint: Nova Biomedical)

Table of Contents:

Abbreviations and substitute words
Preface pp. i-xvii

Section I. The Mechanisms of Cancer Metastasis

• Chapter 1. Definition and classification of tumor metastasis pp. 1-4
• Chapter 2. Mechanisms of metastasis pp. 5-76

Section II. Organ Preference Metastasis

• Chapter 3. Demonstration of organ preference in metastasis through analysis of human cancers in autopsy cases pp. 77-82
• Chapter 4. Experimental verification of organ preference in metastasis pp. 83-98
• Chapter 5. Further investigations required for molecular determinants in organ preference metastasis pp. 99-110

Section III. Metastatic Potential

• Chapter 6. Factors related to metastatic potential of tumor cells pp. 111-120
• Chapter 7. Identification and characterization of metastasis-related adhesion molecules, with special reference to extracellular matrix (ECM) proteins pp. 121-132
• Chapter 8. Carbohydrate expression of tumor cells and its relevance to metastasis and prognosis pp. 133-154

Acknowledgments pp. 155-156
Subject Index
Index pp. 157-161

Authors: Takanori Kawaguchi (Division of Human Life Sciences, Fukushima Medical University School of Nursing, Fukushima, Japan)