Microglia. Biology, Functions and Roles in Disease

Description

The pioneering studies by several leading researchers in the early part of the last century first described the existence of microglial cells both in the early brain developmentand in pathological conditions. Microglial cells were later established to be the resident brain macrophages and immunocompetent cells present ubiquitously in the centralnervous system including the retina in association with other glial cells, neurons and blood vessels. The book should be of interest to cell biologists and neuroscientists in general. Basic scientists, neuroimmunologists, neurologists, neuropathologists and neurosurgeons should find the latest information on microglial cells useful in theircontinued effort in searching and designing potential therapeutic strategies for treatment of neurological disease for which microglial cells are implicated. 

Contents

Preface; Microglia in the developing brain; The Mystic Embryonic Microglia: Its Origin, Function & Seeding; Soldiers of the nervous system: Microglia in surveillance,offense & defense; Microglia secretome: from neurotoxins to neurotrophins; The role of microglia in neurodegenerative disease; Microglia function in Alzheimer's disease;Blood Derived Microglia-Like Cells in Alzheimer's Disease; Microglial functions against amyloid-ß accumulation in brains of Alzheimer's disease