Diagnostic, Prognostic and Therapeutic Value of Gene Signatures (Current Clinical Pathology)

DESCRIPTION

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.

TABLE OF CONTENTS

• Preface
• Chapter 1 Gene signatures and soft tissue sarcomas: status of art and perspectives
  Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini
• Chapter 2 Heterogeneity of breast cancer: gene signatures and beyond
  Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens
• Chapter 3 Gene signatures in CRC and liver metastasis
  Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo
• Chapter 4 Gene signatures in Gastrointestinal Stomal Tumors (GIST)
  Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybyl, and Maria Debiec-Rychter
• Chapter 5 Pancreatic Cancer Genetics
  Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti
• Chapter 6 Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer
  Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei
• Chapter 7 Gene signatures in Gastric Cancer
  Laura Ottini, Mario Falchetti, and Gabriella Nesi
• Chapter 8 Gene signatures in Colorectal Cancer
  Alessandro Lugli and Inti Zlobec
• Chapter 9 The role of epigenetics in cancer: from molecular function to high-throughput assays
  Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia
• Chapter 10 Primary Epithelial Ovarian Neoplasms: New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies
  Bernard Czernobilsky, Leonor Leider-Trejo, and Antonio Russo
• Chapter 11 Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns
  Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone