ABOUT THIS BOOK
Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories. Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve
as a vital laboratory reference for pharmaceutical chemists, medicinal chemists,
and pharmacologists as well as for molecular biologists.
Content Level » Professional/practitioner
Keywords » Drug screening - Lead compounds - Pharmacokinetics - Protein and peptide drugs - Protein-protein interactions - Target identification - Therapeutic agents - Toxicology and toxicity
Related subjects » Biomedical Sciences - Pharmaceutical Science