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Chemical Carcinogenesis (Current Cancer Research)
Penning, T.
1ª Edición Marzo 2011
Inglés
Tapa dura
440 pags
1300 gr
null x null x null cm
ISBN 9781617379949
Editorial HUMANA PRESS
LIBRO IMPRESO
-5%
228,79 €217,35 €IVA incluido
219,99 €208,99 €IVA no incluido
Recíbelo en un plazo de
2 - 3 semanas
ABOUT THIS BOOK
This monograph provides a contemporary account of advances in chemical carcinogenesis.
It promotes the view that it is alteration of the DNA by endogenous and exogenous
carcinogens that ultimately leads to sporadic mutations which are a root cause
of many human cancers. It deals with the metabolic activation of common classes
of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic
aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts
that ensue and their repair mechanisms. It covers advances in structural-biology
that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions
and how this informs the mutational code. It also deals with the concepts of
chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary
texts on the biology of cancer now focus almost exclusively on the molecular
and cell biology of the disease and do not cover the initiating (DNA damaging
events) of chemical carcinogenesis in depth. It is with this perceived gap-in
knowledge that world experts in their particular fields have contributed to
this monograph. This monograph will be an important reference re-source for
students in training, postdoctoral scientists, and senior scientists knowledgeable
in the field.
Content Level » Research
Keywords » Cancer - Cancer Research - Carcinogenesis - Chemical
Related subjects » Cancer Research - Pharmaceutical Science
TABLE OF CONTENTS
1. Historical Overview of Chemical Carcinogenesis
2. Multistage Carcinogenesis
3. Tobacco Smoke Carcinogens and Lung Cancer
4. Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products
5. Heterocyclic Amines: Potential Human Carcinogens
6. Aflatoxins and Hepatocellular Carcinoma
7. Metabolic Activation of Chemical Carcinogens
8. Detoxication of Chemical Carcinogens and Chemoprevention
9. Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts, Carcinogenicity, Structure
and Function
10. Oxidation and Deamination of DNA by Endogenous Sources
11. Lipid Peroxide-DNA Adducts
12. Chemical Carcinogenesis and Epigenetics
13. Nucletoide Excision Repair From Bacteria to Humans: Structure-Function Studies
14. Base Excision Repair: Role of DNA Polymerase b in Late Stage Base Excision
Repair
15. O6-Alkylguanine-DNA alkyltransferase
16. By-Pass DNA Polymerases
17. Mutagenesis: The Outcome of Faulty Replication of DNA
18. p53 and Ras-Mutation
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