Cancer Stem Cells in Lung Cancer. Cancer Etiology, Diagnosis and Treatments

Description:

Of the many markers for cancer stem cells (CSCs) in lung cancer reported to date, the cell surface antigen CD133, nuclear â-catenin accumulation, the side population phenotype, and high aldehyde dehydrogenase (ALDH) activity seem to be most reliable. This new book reviews the results of studies on lung CSCs and discusses the significance of these markers from a biological, pathological, and clinical viewpoint. Twenty-seven lung cancer cell lines (nine small cell lung carcinoma (SCLC) cell lines and eighteen non-small cell lung carcinoma (NSCLC) cell lines) were examined for mRNA and protein expression and fractions of cells with activity.

Table of Contents:

• Introduction
• Stem Cells in Healthy and Injured Lung
• Origin of CSCs in Lung Cancers
• CD133
• Side Population
• Aldehyde Dehydrogenase
• Other Lung CSC Markers
• Signaling Pathways in CSCs of Lung Cancers
• Stem Cells in Healthy and Injured Lung
• Other Signaling Pathways and Transcription Factors in Lung CSCs
• CSC Niche
• Brief Summary of Lung CSC Markers and Potential Problems
• ALDH mRNA Expression - Its Correlation with the Most Common CSC
  Marker CD133
• ALDH Protein Expression in Lung Cancer Cell Lines
• ALDH Activity in Lung Cancer Cell Lines
• Primary Structure of ALDH1A1 mRNA
• Post-Translational Modification of ALDH1A1 Protein
• ALDH Protein Expression in Primary Lung Cancers
• Conclusion
• Index

Authors:

Koji Okudela, Hitoshi Kitamura, Noriyuki Nagahara and Akira Katayama (Yokohama City University, Yokohama, Japan)