Neutrophils in Biological Age and Longevity

Description:

Aging is a heterogeneous process with a progressive and general decrease of the organism functions that leads to a lower ability to adaptively react to changes and preserve homeostasis. Consequently, with aging there is an increase in vulnerability to age-associated pathologies or simply the impairment of functions that leads to death. There are different rates of age-related physiological changes and the “biological age” determines the level of aging experienced by each individual and therefore his/her life expectancy. This new book discusses research which suggests that the functional parameters studied in neutrophils may be useful markers of "biological age" and predictors of longevity.

Table of Contents:

CHAPTER 1. INTRODUCTION

CHAPTER 2. THE AGING PROCESS, LONGEVITY AND BIOLOGICAL AGE

CHAPTER 3. THEORIES OF AGING. THE INTEGRATED THEORY OF AGING

CHAPTER 4. THE IMMUNE SYSTEM AS A HOMEOSTATIC SYSTEM. THE PSYCHO-NEURO-ENDOCRINE-IMMUNE COMMUNICATION AND ITS ALTERATION WITH AGING

CHAPTER 5. IMMUNOSENESCENCE AND AGE-RELATED CHANGES IN THE INNATE IMMUNITY

CHAPTER 6. FUNCTIONS OF NEUTROPHILS AND AGE-RELATED CHANGES

CHAPTER 7. THE IMMUNE SYSTEM, A MARKER OF BIOLOGICAL AGE AND PREDICTOR OF LONGEVITY

CHAPTER 8. THE ROLE OF OXIDATIVE STRESS AND INFLAMMATORY STRESS IN
IMMUNOSENESCENCE

CHAPTER 9. THE ROLE OF THE PHAGOCYTIC CELLS IN OXI-INFLAMM-AGING

CHAPTER 10. INFLUENTIAL FACTORS OVER THE FUNCTIONAL AND REDOX PARAMETERS IN NEUTROPHILS

CHAPTER 11. NEUTROPHILS AND THEIR ROLES IN DISEASE

CHAPTER 12. STRATEGIES TO REVITALIZE THE NEUTROPHIL FUNCTIONS IN AGING

CHAPTER 13. CONCLUSION

INDEX

Authors: Patricia Alonso-Fernández (Hospital Infanta Leonor, Madrid, Spain), Ianire Maté and Mónica De la Fuente (Complutense University, Madrid, Spain)