Vascular dementia is the second most common form of dementia after Alzheimer's disease in older adults. The term refers to a group of syndromes caused by different mechanisms all resulting in vascular lesions in the brain. Early detection and accurate diagnosis are important, as vascular dementia is at least partially preventable.
Risk factors for vascular dementia include hypertension, smoking, hypercholesterolemia, diabetes mellitus, and cardiovascular and cerebrovascular disease. This book presents current research from across the globe in the study of vascular dementia, including GRK2 overexpression in the context of early Alzheimer disease pathogenesis; vitamin deficiencies and vascular dementia; biofluid markers as potential markers for vascular dementia; and the epidemiology of vascular dementia. (Imprint: Nova Biomedical Press)
Table of Contents:
- Vascular Risk Factors, Brain Changes and Cognition: The Role of Metabolic Syndrome
(Bàrbara Segura, María Ángeles Jurado, Department of Psychiatry and Clinical Psychobiology, Faculty of Psychology, University of Barcelona, Barcelona, Spain, and others)
- Oxidative Stress Induced Vascular Hypoperfusion, Mitochondrial Failure Are Missing Links for the Development of Alzheimer Disease
(Gjumrakch Aliev, Hector H. Palacios, Mark E. Obrenovich, Dmitry Gokhman, Valentin Bragin, Arturo Solís Herrera, School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, Georgia, USA, and others)
- GRK2 Overexpression is a Primary Hallmark of Vascular Hypoperfusion and Mitochondrial Lesions during Early Alzheimer Disease: New Target for Drug Treatment?
(Gjumrakch Aliev, Hector H. Palacios, Arturo Solís Herrera, Mark E. Obrenovich, School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, Georgia, USA, and others)
- Mitochondrion Selective Antioxidants as Drug Treatments for Alzheimer Disease
(Gjumrakch Aliev, Hector H. Palacios, Brandi Betts, Mark E. Obrenovich, Jerzy Leszek, Dmitry Gokhman, Valentin Bragin, Arturo Solís Herrera, Department of Health Science and Healthcare, University of Atlanta, Atlanta, Georgia, USA, and others)
- What are the Roles of Vitamins in Vascular Dementia?
(Emel Koseoglu, Erciyes University, Medicine Faculty, Neurology Department, Kayseri, Turkey)
- Vascular Factors on Alzheimer’s Disease
(Iulek Gorczevski, Andréa Heisler, Márcia Chaves, Matheus Roriz-Cruz, Divisions of Neurogeriatrics and Stroke, Department of Neurology, Federal University of ´Rio Grande do Sul´ State, Brazil)
- New Concepts on Vascular Dementia
(Matheus Roriz-Cruz, Sheila O.C. Martins, Márcia L. Chaves Divisions of Neurogeriatrics and Stroke, Department of Neurology, Federal University of ‘Rio Grande do Sul’ state, Brazil)
- Are Vascular, Alzheimer and Mixed Dementias Distinctive Entities?
(Nora Silvana Vigliecca, Consejo Nacional de Investigaciones Científicas y Técnicas de la Argentina, (CONICET) , Cordoba, Argentina, and others)
- Biofluid Protein Biomarkers for the Diagnosis of Vascular Dementia
(Anja Hviid Simonsen, Gunhild Waldemar, Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark)
- Apathy Associated With Subclinical Brain Ischemic Lesions and Vascular Risk Factors
(Hiroshi Yao, Yuki Takashima, Takahiro Mori, Manabu Hashimoto, Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan)
- Caudate Nucleus Volumes in the Leukoaraiosis and Disability in the Elderly Study (LADIS) – A Pilot Case-Control Study of Longitudinal Change
(Jeffrey Chee Leong Looi, Gabriela Spulber, Per Julin, Leif Svensson, Olof Lindberg, Lisa Botes, Yi Zhang, Eva Örndahl, Lars-Olof Wahlund, Research Centre for the Neurosciences of Ageing, Academic Unit of Psychological Medicine, Australian National University Medical School, The Canberra Hospital, Canberra, Australia, and others)
- Neuroepidemiology of Vascular Dementia
(Masahiro Nakatsuka, Kenichi Meguro, Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan)
- Validation of Two Short Dementia Screening Tests in Indonesia ^
(Eef Hogervorst, Fidiansjah Mursjid, Raden Irawati Ismail , Sabarinah Prasetyo, Martina Nasrun, Mochtar, Theresia Ninuk, Stephan Bandelow, Subarkah, Linda Kusdhany, and Tri Budi W. Rahardjo, Loughborough University, SSE&Health Sciences, United Kingdom,and others)
- Cognitive Function and Hypertension: Pathophysiology and Mechanisms ^
(Rakesh Shukla, Kashif Hanif, Division of Pharmacology, Central Drug Research Institute, CSIR, Chattar Manzil, Lucknow, UP, India)