Hemostasis and Thrombosis. Basic Principles and Clinical Practice

Description

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.

Features

NEW to the Sixth Edition…

• A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.
• Full color throughout
• A companion website that offers full text online and an image bank.
• A new introductory section of chapters on basic sciences as related to the field
• Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
• Overview chapters preceding each section address broad topics of general importance.

Table of Contents

PART I: INTRODUCTION TO THE FIELD OF HEMOSTASIS AND THROMBOSIS

Chapter 1. History of the Field –
William C. Aird and Gilbert C. White, II

Chapter 2. Molecular Evolution of the Vertebrate Blood Coagulation System –
Marianne A. Grant and William C. Aird

Chapter 3. Molecular and Clinical Genetics –
Lesley Everett, Karl C. Desch, and David Ginsburg

Chapter 4: Coagulation Enzymology –
Sriram Krishnaswamy

Chapter 5: Cell Biology, Protein Processing, and Cell Signaling –
Randal J. Kaufman and Laura Popolo

Chapter 6: Cellular and Molecular Immunology –
Andrew H. Lichtman

Chapter 7: Biostatistics and Epidemiology: The Basic Science of Clinical Research –
Kerry L. Lee

PART II: BASIC HEMOSTASIS AND THROMBOSIS

SECTION A: COAGULATION & FIBRINOLYSIS

Chapter 8: Overview of Basic Coagulation and Fibrinolysis –
Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett

Chapter 9: The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression –
Dominic W. Chung, Wengfeng Xu, and Earl W. Davie

Chapter 10: Genetics of Coagulation Proteins –
Rodney M. Camire and Paris Margaritis

Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation –
George J. Broze, Jr. and James H. Morrissey

Chapter 12: Factors V and VIII –
Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel

Chapter 13: Structure and Function of von Willebrand Factor –
Sandra L. Haberichter and Robert R. Montgomery

Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins –
Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj

Chapter 15A: Factor XI –
Peter N. Walsh and David Gailani

Chapter 15B: The Factor XII-driven Plasma Contact System –
Thomas Renne

Chapter 16: Fibrinogen Structure and Function –
John W. Weisel and Carl-Erik Dempfle

Chapter 17: Factor XIII –
Cedric Duval, Helen Philippou, and Robert A. S. Ari

Chapter 18: Antithrombin and the Serpin Family –
Susan C. Bock

Chapter 19: Protein C and S and Thrombomodulin System –
Laurent O. Mosnier and John H. Griffin

Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis –
Nuala A. Booth and Nicola J. Mutch

Chapter 21: Inhibitors of Fibrinolysis –
Björn Wiman and Anna Ågren

SECTION B: PLATELET BIOLOGY

Chapter 22: Overview of Platelet Structure and Function –
Joel S. Bennett and Gilbert C. White, II

Chapter 23: Platelet Production: Cellular and Molecular Regulation –
Elisabeth Cramer-Bordé and William Vainchenker

Chapter 24: Megakaryocyte Structure and Platelet Biogenesis –
Joseph E. Italiano, Jr. and John H. Hartwig

Chapter 25: Thrombopoietin –
Kenneth Kaushansky and Ian Hitchcock

Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V –
Michael C. Berndt, and Robert K. Andrews

Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa –
Feng Ye and Mark H. Ginsberg

Chapter 27: Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity –
Thomas J. Kunicki and Diane J. Nugent

Chapter 28: The Basis for Platelet Adhesion –
Brian Savage and Zaverio M. Ruggeri

Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis –
David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson

Chapter 30: Platelets and Collagen –
Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung

Chapter 31: Integrin aIIb ß3 and Platelet Aggregation –
Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, Edward F. Plow, and Sanford J. Shattil

Chapter 32: Molecular Basis for Platelet Secretion –
Shaojing Ye and Sidney W. Whitehart

Chapter 33: Platelet Signal Transduction –
Charles S. Abrams and Lawrence F. Brass

Chapter 34: Platelet Prostaglandin Metabolism –
Tilo Grosser and Garret A. FitzGerald

Chapter 35: The Role of Platelets in Blood Coagulation –
Peter N. Walsh

Chapter 36: Blood-Borne Microparticles –
José López and Swaminathan Murugappan

SECTION C: VASCULAR BIOLOGY - William C. Aird

Chapter 37: Overview of Vascular Biology –
William C. Aird

Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis –
Aernout Luttun and Peter Carmeliet

Chapter 39: Rheology and Vessel Wall Stress –
Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez

Chapter 40: Nitric Oxide –
Bradley A. Maron and Thomas Michel

Chapter 41: Blood Vessel Wall in Health and Disease –
Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain

Chapter 42: Endothelial Cell Function –
William C. Aird

Chapter 43: Role of Endothelium in Hemostasis –
Michael J. Krisinger and Edward M. Conway

Chapter 44: Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway –
Wolfram Ruf

Chapter 45: Heparin and Vascular Proteoglycans –
Douglas M. Tollefsen and Lijuan Zhang

Chapter 46: Endothelial Cell-Blood Cell Interactions –
Klaus Ley

Chapter 47: Leukocyte Function and Contribution to Disease –
Edith van de Vijver and Taco W. Kuijpers

Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction –
Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel

PART III: DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL

SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS

Chapter 49: Overview of Inherited Hemorrhagic Disorders –
Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder

Chapter 50: Differential Diagnosis of the Bleeding Patient –
Jill M. Johnsen and Barbara A. Konkle

Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia –
Edward G.D. Tuddenham

Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment –
J. Evan Sadler and David Lillicrap

Chapter 53: Rare Inherited Coagulation Disorders Other than Hemophilia –
Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi

Chapter 54: Afibrogenemias and Dysfibrogenemias –
Dennis K. Galanakis

Chapter 55: Familial Multiple Coagulation Factor Deficiencies –
Bin Zhang and David Ginsburg

Chapter 56: Clinical Disorders of Fibrinolysis –
Daphne Stewart, Charles W. Francis, and Victor J. Marder

Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies –
Charles RM Hay

Chapter 58: Laboratory Markers of Coagulation and Fibrinolysis –
Kenneth A. Bauer and Helen A. Ireland

SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS

Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders –
Joel S. Bennett

Chapter 60: Differential Diagnosis of Thrombocytopenia –
Joel S. Bennett and Charles S. Abrams

Chapter 61: Immune Thrombocytopenic Purpuraand Posttransfusion Purpura –
Howard A. Liebman, Douglas B. Cines, and James B. Bussel

Chapter 62: Drug-Induced Thrombocytopenia –
Richard H. Aster and James N. George

Chapter 63: Inherited Thrombocytopenias –
Paquita Nurden and Alan T. Nurden

Chapter 64: Acquired Nonimmune Thrombocytopenia –
Andreas Greinacher and Theodore E. Warkentin

Chapter 65: Hereditary Disorders of Platelet Function –
Joel S. Bennett and A. Koneti Rao

Chapter 66: Acquired Disorders of Platelet Function –
A. Koneti Rao and Joe

About the Author(s)

Victor J Marder MD, Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA

William C Aird MD, Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA

Joel S Bennett MD, Professor of Medicine, University of Pennsylvania, Philadelphia, PA

Sam Schulman MD, Professor of Medicine, McMaster University, Hamilton, Ontario, Canada

Gilbert C White II MD, Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI