Targeted Cancer Therapy

About this book

• Details the drugs that directly impact the molecular abnormality that characterizes a tumor
• Examines personalized medicine based on an understanding of underlying biologic mechanisms
• Covers new emerging technologies in target identification, drug discovery, molecular markers, and imaging, which are rapidly changing the face of cancer
• Looks at how to design drug combinations that can overcome drug resistance

In the era of personalized medicine, cancer treatment has become a model for the use of targeted therapeutics. Leaving behind the "one size fits all" approach to cancer care, this book provides the practicing oncologist with an overview of the advances in treatment and an understanding of the implementation of new therapeutic agents. Targeted Cancer Therapy is divided into twenty chapters covering specific hematologic malignancies and solid tumors, targeted and functional imaging, and combination therapies. Each disease specific chapter includes up-to-date information on investigational and FDA approved therapies which will enhance the reader’s ability to prescribe effective drug regimens. This includes combinations of therapies and therapeutic modalities to overcome drug resistance.

In a rapidly changing field, this book will enable clinicians to improve their ability to practice personalized health planning, make early diagnoses, and select optimal drugs for each patient with predictable side effects and outcomes. Poised to change the landscape in oncology, Targeted Cancer Therapy is essential for practicing and academic physicians, fellows, and residents.

Written for » Professional/practitioner

Keywords » Combination Therapy - Cytostatic Agents - Cytoxic Agents - Molecular Markers - Monoclonal Antibodies - Personalized Medicine - Targeted Therapy

Related subjects » Cancer Research - Internal Medicine - Oncology & Hematology

Table of contents

• Chapter 1 Perspectives: Bench to Bedside and Back
  Jennifer Wheler, MD and Razelle Kurzrock, MD, FACP
• Chapter 2 Targeted Therapy in Acute Myelogenous Leukemia
  Elihu Estey, MD
• Chapter 3 Targeted Therapy in Breast Cancer
  Barbara S. Craft, MD; Stacy Moulder, MD, MSCI
• Chapter 4 Targeted Therapy in Chronic Lymphocytic Leukemia
  Apostolia-Maria Tsimberidou, MD, PhD; Michael J. Keating, MD
• Chapter 5 Targeted Therapy in Chronic Myeloid Leukemia
  Elias Jabbour, MD; Jorge Cortes MD, Hagop Kantarjian, MD
• Chapter 6 Targeted Therapy in Colorectal Cancer
  Scott Kopetz, MD
• Chapter 7 Targeted Therapy in Non-small Cell Lung Cancer
  David J. Stewart, MD, FRCPC
• Chapter 8 Targeted Therapy in Lymphoma
  Amanda Wedgwood, MSN; Anas Younes, MD
• Chapter 9 Targeted Therapy in Melanoma
  Michael Davies, MD, PhD; Sunil Patel, MD; Kevin B. Kim, MD
• Chapter 10 Targeted Therapy in Multiple Myeloma
  Yuhong Zhou, MD; Raymond Alexanian, MD; Michael Wang, MD
• Chapter 11 Targeted Therapy in Myelodysplastic Syndrome
  Alfonso Quintás-Cardama, MD; Hagop Kantarjian, MD; Guillermo Garcia-Manero, MD; Jorge Cortes, MD
• Chapter 12 Targeted Therapy in Epithelial Ovarian Cancer
  Maurie Markman, MD
• Chapter 13 Targeted Drug Therapy in Pancreatic Cancer
  Don L. Gibbons, MD, PhD; Robert A. Wolff MD,
  Gauri Varadhachary, MD
• Chapter 14 Targeted Therapy in Prostate Cancer
  Amado J. Zurita MD; John F. Ward, MD; Jeri Kim, MD
• Chapter 15 Targeted Therapy in Renal Cell Carcinoma
  Eric Jonasch, MD; Nizar Tannir, MD
• Chapter 16 Targeted Therapy of Sarcoma
  Joseph Ludwig, MD; Jonathan C. Trent , MD, PhD
• Chapter 17 Targeted and Functional Imaging
  Vikas Kundra, MD, PhD; Dawid Schellingerhout, MD; Edward F. Jackson, PhD
• Chapter 18 Combining Targeted Therapies
  David Hong, MD; Lakshmi Chintala, MD
• Chapter 19: Drug Development in Cancer Medicine: Challenges for Targeted Approaches
  Luis H. Camacho, MD, MPH
• Chapter 20: Toward Personalized Therapy for Cancer
  Sarah J. Welsh, PhD, Garth Powis, DPHIL