Biomolecular Nmr Spectroscopy (Advances in Biomedical Spectroscopy, Vol. 3)

DESCRIPTION

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled Biomolecular NMR Spectroscopy, focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: (i) sample preparation, (ii) structure and dynamics of proteins, (iii) structure and dynamics of nucleic acids and protein-nucleic acid complexes and (iv) rapid and hybrid techniques, including the latest advances in NMR data acquisition and structural analysis, and approaches that combine NMR data with data from complementary physical techniques. The book will be a valuable resource for experienced scientists in academia, government and public services and in industry. It will also be suitable for newcomers and graduate students entering the field of biomolecular NMR spectroscopy.

TABLE OF CONTENTS

• Sample Preparation
• Advances in Cell-Free Protein Synthesis for NMR Sample Preparation
• RNA for NMR
• Isotope Labeling of Larger DNAs for NMR Structural Studies
• Structure and Dynamics of Proteins
• NMR Studies of Large Protein Systems
• Experimental and Computational Characterization of Disordered States of Proteins
• New Approaches for the Study of Paramagnetic Metalloproteins
• Solid-State NMR on Membrane Proteins: Methods and Applications
• Solid-State NMR of Membrane-Acting Antimicrobial Peptides
• NMR Spectroscopy Inside Prokaryotic and Eukaryotic Cells
• Relaxation Dispersion Studies of Enzyme Motions
• Structure and Dynamics of Nucleic Acids and Protein-Nucleic Acid
• Complexes
• RNA Structure Determination by NMR: Combining Labeling and Pulse Techniques
• NMR Spectroscopy for Investigating Larger Nucleic Acids
• How to Study the Structure and Dynamics of Protein-RNA Complexes by NMR Spectroscopy
• Investigating RNA and DNA Dynamics through Nuclear Magnetic Resonance
• Rapid and Hybrid Techniques
• Fast Acquisition Methods in Multidimensional NMR
• Automated Protein Structure Determination from NMR Data
• Advances in NMR-Based Structural Genomics
• NMR Screening Methods for Drug Discovery
• Hyphenated NMR Techniques
• NMR and Calorimetry of Biological Systems
• NMR and SAXS: A Perfect Marriage and New Approach for RNA Structure Determination