Handbook of Prostate Cancer Cell Research. Growth, Signalling and Survival

Book Description:

Prostate cancer is a disease in which cancer develops in the prostate, a gland in the male reproductive system. It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the prostate to other parts of the body, especially the bones and lymph nodes. Prostate cancer may cause pain, difficulty in urinating, problems during sexual intercourse, erectile dysfunction and other symptoms. However those symptoms are present only in an advanced stage of the disease. Prostate cancer is the most common malignancy diagnosed in men and is the second leading cause of cancer deaths among males. Androgens play a major role in the development of prostate cancer since males castrated during childhood do not develop this disease. Another factor known to be involved in prostate cancer development is age, since the majority of prostate cancer patients are aging men.
Rates of detection of prostate cancers vary widely across the world with South and East Asia detecting less frequently than in Europe, and especially the United States. This new important handbook gathers the latest research from around the globe in this field.

Editors: Alan T. Meridith

Table of Contents:

• Natural Products Action on Prostate Cancer Cell Growth, Signaling and Survival
  (Jorge A. R. Salvador, Vânia M. Moreira, Laboratório de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Coimbra, Portugal, and others)
• Molecular Imaging in Prostate Cancer: [11c]Choline Pet/Ct
  (M. Picchio, G. Giovacchini, R. Garcia Parra, C. Crivellaro, C. Landoni, L. Gianolli, C. Messa, Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy)
• The Stem Cell Paradigm and its Application to Prostate Cancer – An Old and Yet Still Young Idea
  (Krassimira Todorova, Soren Hayrabedyan, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria and others)
• Interactions between the Androgen Receptor and Other Signaling Pathways Implicated in Prostate Cancer Growth and Development
  (Oluwakemi Obajimi, PhD., Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden, NJ, and others)
• Prostate Stem Cells and Cell Differentiation
  (Guadalupe Aparicio Gallego, Silvia Díaz Prado, Moisés Blanco Calvo, Rosario García Campelo, Javier Cassinello Espinosa, Enrique Grande Pulido, Luís Miguel Antón Aparicio, Oncology Research Unit. Universtiy Hospital A Coruña. A Coruña. Spain, and others)
• Organoselenium Compounds: A Promising Prospect in Prostate Cancer Therapy
  (Carmen Sanmartín and Juan Antonio Palop, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Pamplona, Spain)
• Origin of Oscillations in Molecular Mechanism of Radioresistance of Prostate Carcinoma Cells: Implications for Successful Therapy
  (Petar M. Mitrasinovic, Institute for Multidisciplinary Research, Belgrade, Serbia)
• Post-translational Regulation of Androgen Receptor in Proliferation of Prostate Cancer Cells
  (Shigetsugu Hatakeyama, MD., Ph.D., Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan)
• Cytotoxic Effects of Rhenium (I) Carbonyl Complexes On Prostate Cancer Cell Lines
  (Dejene K. Orsa, Columbus R. Nettles, Saroj K. Pramanik, Maurice O. Iwunze, George E. Greco, Jeanette A. Krause, Santosh K. Mandal, Morgan State University, Department of Chemistry, Baltimore, MD, and others)
• The Role of Cox-2 in Prostate Carcinoma: Therapeutical Implications
  (Díaz Prado S., Valladares Ayerbes M, Grande Pulido E, Cassinello Espinosa J, Antón Aparicio L.M, Medicine Department, Faculty of Healthy Sciences. University of A Coruña, Spain, and others)
• Cell Cycle Signaling Networks in Prostate Cancer: E2F Target Genes Play a Predominant Role in Radiation Response and are Potentially Co-regulated by p53 and WT1
  (Kamini Singh, Kurtis Eisermann, Helen Piontkivska, Gail Fraizer, Alexandru Almasan, Department of Cancer Biology, Lerner Research Institute Cleveland, OH and others)
• Molecular Genetic Alterations in Prostate Cancer Microenvironment
  (Tatiana V. Kekeeva , M.V. Nemtsova , Y.Y. Andreeva , G.A. Frank , I.G. Rusakov , and Dmitri V. Zaletayev, Institute of Molecular Medicine, Sechenov Moscow Medical Academy, Moscow, Russian Federation, and others)
• Prostate Cancer Cell Growth and Death: Complex Roles of Pro- and Anti-Oncogenic Protein Signaling
  (Qun Lu, Jiao Zhang, and Yan-Hua Chen, Department of Anatomy and Cell Biology, Leo Jenkins Cancer Center, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, U.S.A; and others)
• Key Role of Bone Microenvironment on Prostate Cancer Bone Metastasis: The Tumor Sanctuary And Source of Prostate Cancer Cell Survival, Migration and Development in Bone
  (Mori, K., Heymann, D., Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga, Japan, and others)
• Prostate Cancer: Are We Close To Knowing the Disease?
  (B. Shannan, D. Boothman, G. Akhras, College of Pharmacy, International University for Science and Technology, Damascus, Syria, and others)
• Implications of Lysophosphatidic Acid Signaling and Receptor-mediated Mechanisms Contributing to the Development of Prostate Carcinoma
  (Mandi M. Murph, Department of Pharmacology and Biomedical Sciences, The University of Georgia, College of Pharmacy, R.C. Wilson Pharmacy Building, Athens, Georgia)
• Redox State and Prostate Cancer Behavior
  (Luksana Chaiswing and Terry D. Oberley, Pathology and Laboratory Medicine Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin and others)
• Telomerase mRNA Detection in Serum of Patients with Prostate Cancer
  (Luca Dalle Carbonare, Maria Teresa Valenti, Sandro Giannini, Giuseppe Realdi, Vincenzo Lo Cascio, department of Biomedical and Surgical Sciences, Clinic of Internal Medicine D – University of Verona – Italy, and others)
• Piezoelectric Interaction with Prostatic Crystalloids May Explain the Relationship between Environmental Electromagnetic Field and Prostate Cancer
  (Kamyar Ghabili , Paul S. Agutter , Mohammadali M. Shoja, Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Daneshgah St., Tabriz, Iran, and others)
• Developments, Directions and Problems in the Management of Prostate Cancer
  (Oluwakemi Obajimi, PhD., Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden, NJ, and others)

Index