Diabetes and the Brain

About this book

The following is a justification and brief description of the sections of the book. The first 2 sections provide a general update on diabetes for neurologists and of stroke and dementia for internists, endocrinologist, and all providers who work with the diabetes patients.

Section 3 describes how acute derangements in glucose metabolism in persons with diabetes affect the brain and provides an update of the management of these conditions. This section also provides an overview of the relation between diabetes and stroke and the management of hyperglycemia in acute stroke patients.

Section 4 reviews the cognitive complications in type 1 and type 2 diabetes in different stages of life and addresses depression and central pain mechanisms.

Section 5. Addresses the mechanisms explaining the cognitive consequences of diabetes.

Written for:

Neurologists and of stroke and dementia for internists, endocrinologist, and all providers who work with the diabetes patients.

Keywords:

Cognition
Dementia
Diabetes
Diabetic Encephalopathy
Diabetic Neuropathy
Stroke

Table of contents

Section 1 update on diabetes for neurologists

1. Type 1 diabetes
(epidemiology, diagnosis, co-morbidity-complications, management)

2. Type 2 diabetes
(epidemiology, diagnosis, co-morbidity-complications, management)

Section 2 update on stroke and dementia for diabetologist

1. Acute ischemic stroke
(epidemiology, diagnosis, co-morbidity-complications, acute treatment, secundary prevention)
Dr HB vand der Worp
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

2. Neuropsychological assessment
Dr Augustina MA Brands, Prof Edward HF de Haan
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

3. Clinical evaluation of cognitive dysfunction and dementia
Prof. Philip Scheltens
Dept. Neurology / Alzheimer Center
VU University Medical Center
email: p.scheltens@vumc.nl

4. Current treatmet of cognitive dysfunction and dementia

Section 3: Acute cerebral disturbances in diabetes

1. Hypoglycemia
Professor Brian M. Frier,
Department of Diabetes, Royal Infirmary of Edinburgh,
51 Little France Crescent,
Edinburgh, EH16 4SA, UK. E-mail: brian.frier@luht.scot.nhs.uk

2. Ketoacidosis and hyperglycemic hyperosmolar state

3. Diabetes and stroke
Professor Boris N Mankovsky
Institute of Endocrinology,
Kiev,
Ukraine
mankovsk@uprotelnetua

4. Hyperglycemia in acute stroke
Nyika D Kruijt, Y Roos,
Department Neurology Academic Medical Center
University of Amsterdam
P.O. Box 22700
1100 DE Amsterdam
The Netherlands N.D.Kruijt@amc.uva.nl

Section 4: Long term cerebral complications in diabetes

1. Cognition in children with type 1 diabetes
Professor Christopher M. Ryan
Department of Psychiatry,
University of Pittsburgh School of Medicine,
Pittsburgh, PA USA
ryancm@upmc.edu

2. Cognition in adults with type 1 diabetes
Professor Ian J Deary
Department of Psychology,
University of Edinburgh,
Edinburgh, U.K.
I.Deary@ed.ac.uk

3. Cognition in type 2 diabetes and in pre-diabetic stages
Esther van den Berg
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

4. Diabetes and dementia
Jose A. Luchsinger, MD MPH
Assistant Professor of Medicine
Columbia University
PH9E-105
630 West 168th Street
New York, NY 10032
jal94@columbia.edu

5. Diabetes and depression
Professor Patrick J. Lustman, PhD,
Department of Psychiatry,
Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8134,
St. Louis, MO 63110. E-mail: lustmanp@wustl.edu

6. Central nervous system involvement in painful diabetic neuropathy
Professor Solomon Tesfaye MD FRCP
Consultant Physician/Honorary Professor of Diabetic Medicine (University of Sheffield),
Royal Hallamshire Hospital,
Glossop Road,
Sheffield S10 2JF, UK
e mail: solomon.tesfaye@sth.nhs.uk

Section 5: experimental models and pathophysiology

1. Animal models for "diabetic encephalopathy"
Geert-Jan Biessels, MD PhD
Department of Neurology, G03.228
University Medical Center
PO Box 85500
3508 GA Utrecht
the Netherlands

2. Pathofysiology of diabetic encephalopathy
Professor Anders AF Sima
Department of Pathology,
Wayne State University, 540 E.
Canfield Ave. Detroit, MI 48201, USA. asima@med.wayne.edu

3. Glucose, insulin, cognitive decline and dementia
Professor Suzanne Craft
Geriatric Research, Education, and Clinical Center,
Veterans Affairs Puget Sound Health Care System,
Department of Psychiatry and Behavioral Sciences,
University of Washington School of Medicine, Seattle, WA, USA. scraft@u.washington.edu

4. Effects of insulin and diabetes on neurovascular function and hippocampal size throughout the lifespan
Professor Antonio Convit
New York University School of Medicine,
Department of Psychiatry, 560 First Avenue,
Center for Brain Health, HN-400, New York, NY 10016, USA.
antonio.convit@med.nyu.edu