Mechanisms of the Glaucomas. Disease Processes and Therapeutic Modalities (Ophthalmology Research)

About this book

(Pending)
The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.

Written for:

Basic scientists

Keywords:

• Disease
• Glaucomas
• Mechanisms
• Modalities
• Processes
• Shields
• Therapeutic

Table of contents

Epidemiology of Glaucoma: Introduction

1. Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the United States - Joshua D. Stein, MD, MS, and Paul P. Lee, MD, JD
2. Epidemiology of and Risk Factors for Primary Open Angle Glaucoma - Paulus T.V.M. de Jong, MD, PhD1,2,3 Nomdo M. Jansonius, MD, PhD3,4 Roger C.W.Wolfs, MD, PhD3,5 Richard H.C. Zegers, MD.2,3
3. The Reykjavik Eye Study on the Prevalence of Glaucoma in Iceland and Identified Risk Factors - Fridbert Jonasson MD, Arsaell Arnarsson MSc, Thor Eysteinsson Ph D.
4. Defined Glaucoma in Chinese Population - Chun Zhang1, Ningli Wang2, Wei Wang1
5. The Wroclaw Epidemiological Study: Screening Possibilities of Glaucoma Detection - Radoslaw Kaczmarek, MD; Maria H. Nizankowska, MD, PhD

Mechanisms of Intraocular Pressure Elevation in the Glaucomas: Introduction

6. Pre Trabecular Mechanisms of Intraocular Pressure Elevation - Sarwat Salim, MD and M. Bruce Shields, MD
7. Trabecular Mechanisms of Intraocular Pressure Elevation - Douglas H Johnson, MD1 and Elke Lutjen-Drecoll, MD2
8. Trabecular Mechanisms: Pseudoexfoliation Syndrome - Ursula Schlötzer-Schrehardt, PhD and Gottfried O.H. Naumann, MD
9. Posttrabecular Mechanisms with Elevated Episcleral Venous Pressure - Augusto Paranhos, Jr, João Antonio Prata. Jr, Paulo Augusto de Arrude Mello, and Felicio Aristóteles da Silva
10. Angle Closure Glaucomas: Anterior (Pulling) Mechanisms - Malik Y. Kahook, MD1 & Joel S. Schuman, MD2
11. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms With Pupillary Block - Hiromu Mishima
12. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms without Pupillary Block - Yaniv Barkana, MD Clement C. Tham, MD, Syril K. Dorairaj, MD, Robert Ritch, MD

Genetics of Glaucoma: Introduction

13. Genetics and Glaucoma Susceptibility - Karim F. Damji1 and R. Rand Allingham2
14. Myocilin Mutations and their Role in Open Angle Glaucoma - Dr Paul N. Baird, BSc Hons, PhD
15. The Functional Role of Myocilin in Glaucoma - Ernst R. Tamm, MD
16. Role of Cyp1b1, Optineurin and WDR36 Gene Mutations in Glaucoma - Mansoor Sarfarazi, Ph.D.1, Sharareh Monemi, M.D., Ph.D.1, Dharamainder Choudhary, Ph.D.1-2, Tayebeh Rezaie, Ph.D.1 and John Schenkman, Ph.D.2
17. Genetic Association in Primary Open Angle Glaucoma -Fuu-Jen Tsai, MD, PhD,1 Hui-Ju Lin, MD
18. Apo E Polymorphisms and Severity of Open Angle Glaucoma - Chi Pui Pang, Clement Chee Yung Tham, Dennis Shun Chiu Lam

Molecular and Cellular responses in the eye to Glaucoma

19. Changes in Aqueous humor dynamics with Age and Glaucoma - James C. H. Tan, B’Ann T. Gabelt, and Paul L. Kaufman
20. Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis: Elevated Intraocular Pressure and Stretch - Teresa Borrás, Ph.D.
21. Reactive Astrocytes in the Glaucomatous Optic Nerve Head: Protective and Destructive Mechanisms - M. Rosario Hernandez, DDS and Bin Liu
22. Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma: Mechanisms and Therapeutic Strategies. - Dong Feng Chen, M.D., Ph.D. and Kin-Sang Cho, Ph.D.
23. Proteomics in Defining Pathogenic Processes Involved in Glaucomatous Neurodegeneration - Gülgün Tezel, M.D.
24. Proteomic Advances Toward Understanding Glaucoma Mechanisms - Sanjoy K Bhattacharya PhD and John W Crabb PhD
25. Ocular gene Expression in Experimental Glaucoma - Tomonari Ojima, M.D., Ph.D. and Nagahisa Yoshimura, M.D., Ph.D
Ocular Tissue and Psychophysiological Responses in Glaucoma
26. Ocular Biomechanics in Glaucoma - C. Ross Ethier1,2,3, Victor H. Barocas4 and J. Crawford Downs5
27. Intraocular Pressure, Pefusion Pressure and Optic Nerve Energy Metabolism - Einar Stefánsson MD PhD
28. Optic Nerve: Physiology and Mechanisms of Glaucomatous Atrophy - Makoto Aihara, M.D., Ph.D. and Goji Tomita
29. Psychophysiology of Glaucoma: From Form to Function -Chris A. Johnson and Shaban Demirel

Models of Glaucoma

30. The Primate Model of Experimental Glaucoma - Arthur J. Weber, PhD and Suresh Viswanathan, B.Opt., MS, PhD
31. Involvement of Inflammation in a Mouse Model of Inherited Pigmentary Glaucoma -Wei Cao, M.D., Ph.D.
32. Use of Purified Retinal Ganglion Cells for an In Vitro Model to Study Glaucoma - Yasumasa Otori, MD, PhD

Therapeutic Modalities

33. Pharmacological Therapies for Managing Glaucoma - Jess T. Whitson, MD and Nalini K. Aggarwal, MD
34. Redox-Based Therapies for Neuroprotection - Leonard A. Levin, MD, PhD
35. Neuroprotective Signaling Pathways in Glaucoma - Frédéric Lebrun-Julien and Adriana Di Polo
36. Lasers in the Management of the Glaucomas - Mark A. Latinaa1, Navin Prasadb, Jorge A Alvaradoc
37. Mechanisms and Mechanics of Incisional Surgery for Glaucoma - Robert D. Fechtner, MD, Albert S. Khouri, MD
38. Aqueous Shunts - Don Minckler MD, MS and S, Mosaed
39. New Approaches to the Surgical Management of the Glaucomas - Carl B. Camras and M. Bruce Shields