Transforming Growth Factor-Beta in Cancer Therapy vol.2

About this book

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy.

This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.

Written for: Molecular and cell biologists, cancer researchers, pharmacologists

Table of contents

In Memorium for Anita B. Roberts, PhD- John M. McPherson*
Preface- Sonia B. Jakowlew*
Foreward- Carl-Henrick Heldin*
Contributors

Part I. Transforming Growth Factor-ß in Developing and Advanced Cancers

1 Transforming Growth Factor-ß Signaling in Pancreas Development and Pancreatic Cancer
Sushil Rane*, Huei-Min Lin, Ji-Hyeon Lee, and Wan Jiao

2 Role of Transforming Growth Factor-ß (TGF-ß) in the Pathogenesis of Head and Neck Squamous Cell
Carcinoma (HNSCC)
Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, and Xiao-Jing Wang*

3 TGF-ß, Smads and Cervical Cancer
Devarajan Karunagaran* and Goodwin Jinesh

4 TGF-ß Signaling and Biglycan in Pancreatic Cancer
Hendrik Ungefroren*

5 TGF-ß Signaling in Endometrial Cancer
Dagmara Piestrzeniewicz-Ulanska*, David H. McGuinnes, and Grant R. Yeaman

6 TGF-ß Ligands, TGF-ß Receptors, and Lung Cancer
Guiying Wang, Rongmei Zhang, Xiaohua Hu, Jiucun Wang, Lindsey J. Leach, and Zewei Luo*

7 Role of TGF-ß in Osteolytic Bone Metastases
Laurent Bartholin* and Thesesa A. Guise

8 Hormonal Regulation of Transforming Growth Factor-beta in Breast Cancer
Miriam Buck* and Cornelius Knabbe

9 TGF-ß Signaling in Esophageal Cancer
Minoru Fukuchi*, Hiroyuki Kato, and Hiroyuki Kuwano

10 TGF-beta and HER2/ErbB2 and Breast Cancer Progression
Natasa Todorovic-Rakovic*

11 TGF-beta dependent T Cell Regulation in Colitis and Colon Cancer
Christoph Becker* and Markus F. Neurath

12 Role of Transforming Growth Factor-beta in the Kidney - Physiology and Pathology
Elena Gagliardini and Ariela Benigni*

13 Perturbations of TGF-ß Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis
Lawrence A. Wolfraim* and John J. Letterio

14 Transforming Growth Factor-ß in Brain Functions and Dysfunctions
Denis Vivien*, Karim Benchenane, and Carine Ali

15 Inhibition of TGF-ß Signaling in Multiple Myeloma and it's Bone Marrow Environment
Hiroshi Yasui, Teru Hideshima, and Kenneth C. Anderson*

16 Key Roles of Smad3 in TGF-ß Responses in the Prostate
Kyung Song and David Danielpour*

17 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple
Pathways Through Activation of the TGF-ß Type I Receptor
Francis W. Ruscetti*, Salem Akel, Maria Birchenall-Roberts, Zhouhong Cao, and Anita Roberts

Part II. Transforming Growth Factor-ß in Cancer Treatment and Therapy

18 High Throughput Screening of Protein Interaction Networks in the TGFß Interactome: Understanding the
Signaling Mechanisms Driving Tumor Progression
Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor Jurisica, and Jeffrey L. Wrana*

19 Tumor Suppressor and Pro-Progression Roles for TGF-ß in Breast Cancer
Ethan Kohn* and Binwu Tang

20 Tumor Suppressors p53 and TGF-ß Converge to Regulate the Alpha-fetoprotein - Oncodevelopmental
Tumor Marker
Deepti S. Wilkinson and Michelle Craig Barton*

21 TGF-ß1: Roles in DNA Damage Responses
Kumari L. Andarawewa, Julie Kirshner, Joni D. Mott, and Mary Helen Barcellos-Hoff*

22 The Rationale For and Effects of Targeting TGF-beta for Glioma Therapy
Anita B. Hjelmeland* and Jeremy N. Rich

23 Tumor Suppressor Function of TGF-ß1 in T Cells
Ramireddy Bommireddy* and Thomas Doetschman

24 Therapeutic Effects of Adenovirus-mediated Gene Transfer of TGF-ß Signal Antagonists on Undesirable
Epithelial-mesenchymal Transition and Neovascularization
Shizuka Saika*

25 Role of TGF-ß in Tumor Protection and Anti-tumor Immunity
Catherine Bollard* and Cliona M. Rooney

26 Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1
Karen O. Yee and Jack Lawler*

27 Cancer-associated Fibroblasts and the Role of TGF-ß
Patrick Micke*, Aristidis Moustakas, Mitsuhiro Ohshima, and Kai Kappert

28 Adaptive Transfer of Tumor Reactive TGF-ß Insensitive CD8+ T cells for Cancer Therapy
Chung Lee*, Ali Shah, Victoria C. Liu, Irwin I. Park, Larry Y. Wong, Xuemei Huang, Lijun
Huang,Vivian W. Zhou, Terry Medler, Shilajit D. Kundu, Qiang Zhang, and Norm D. Smith

29 DNA Methylation and Histone Deactylation Inhibitors as Potential Therapeutic Agents
for the Re- constitution of TGF-ß Signaling in Breast Cancer
Sudhakar Ammanananchi and Michael G. Brattain*

30 Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-ß, Connective
Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities
David R. Rowley*

31 TGF-ß Signaling and Vascular Morphogenesis
Evangelia Pardali, Zhen Liu, Marion Scharpfenecker, and Peter ten Dijke*

32 Aberrant TGF-beta Signaling in Human Pancreatic Cancer: Translational Implications
Murray Korc*

33 TGF-ß and Stromal Influences Over Local Tumor Invasion
Sylviane Dennier, Alain Mauviel*, and Franck Verrecchia

34 TGF-ß at the Crossroads Between Inflammation, Suppression and Cancer
Nancy L. McCartney-Francis* and Sharon M. Wahl

Part III. Development of Inhibitors of Transforming Growth Factor-ß Signaling for Therapy

35 Transforming Growth Factor-ß (TGF-ß) Signaling Inhibitors in Cancer Therapy
Pran K. Datta* and Jason R. Mann

36 Targeting TGF-ß as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy
Marjan Boerma, Junru Wang, Michael J. Corbley, and Martin Hauer-Jensen*

37 Targeting Transforming Growth Factor-ß in Metastasis: In Vitro and In Vivo Mechanisms
Michael Reiss*

38 Targeted Downregulation of TGF-beta 2 with AP 12009 in Tumor Therapy
Karl-Hermann Schlingensiepen*, Piotr Jachimczak, Birgit Fischer-Blass,
Dagmar Fisher, Heike Specht, Susanne Schmaus, and Reimer Schlingensiepen

39 Modulating TGF-ß Receptor Signaling: A Novel Approach of Cancer Therapy
Ulricke Naumann and Michael Weller*

40 Engineering TGF-ß Traps: Artificially Dimerized Receptor Ectodomains as High Affinity Blockers of TGF-ß Action
Gregory De Crescenzo, Heman Chao, John Zwaagstra, Yves Durocher, and Maureen D. O'Connor-McCourt*

41 The Use of Virtual Screen in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5
Kinase Inhibitors in Oncology
Leona E. Ling*, Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Doreen J. Lepage, Erika L. Silverio, Michael J. Corbley, Lihong Sun, James L. Papadatos, Feng Shan, Timothy Pontz, H.-Kam Cheung, Xiamei Zhang, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman, Scott Bowes, Serene Josiah, and Wen-Cherng Lee

42 Soluble Type II Transforming Growth Factor-ß Receptor Inhibits Tumorigenesis by Augmenting Host
Anti-tumor Immunity
Eiji Suzuki* and Steven M. Albelda

43 Reversal of EMT by Small-Molecule Inhibitors of TGF-ß Type I and II Receptors: Implications for
Carcinoma Treatment
Markus D. Lacher, W. Michael Korn, and Rosemary J. Akhurst*

44 Soluble TGF-ß Type III Receptor Suppresses Malignant Progression of Human Cancer Cells
Abhik Bandyopadhyay and Lu-Zhe Sun*

45 Targeting Smad-dependent TGF-ß Signaling with Peptide Aptamers
F. Michael Hoffmann*, Qiqi Cui, S. Kyun Lim, and Bryan M. Zhao

46 Rationale for Anti-TGFß Antibody Therapy in Oncology
Frank Hsu, Beverly A. Teicher*, and John M. McPherson