Transforming Growth Factor-Beta in Cancer Therapy vol.1

About this book

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.

This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.

Written for: Molecular and cell biologists, cancer researchers, pharmacologists

Table of contents

In Memorium for Anita B. Roberts, PhD- John M. McPherson*
Preface- Sonia B. Jakowlew*
Foreward- Michael B. Sporn*
Contributors

Part I. Basic Concepts of TGF-ß Signaling in Normal Physiology and Cancer Pathobiology

1 Component Hardware for Transforming Growth Factor-ß Signal Transduction: TGF-ß Ligands, TGF-ß Receptors, and Smads
Sonia B. Jakowlew*

2 TGF-ß Signaling in Homeostasis and Cancer
Joan Seoane*

3 TGF-ß Availability: Latent TGF-ß and Latent TGF-ß Binding Proteins
Vesna Todorovic* and Daniel B. Rifkin

4 Biological Functions of Latent TGF-ß Binding Proteins and Activation of TGF-ß
Marko Hyytiäanen*, Katri Koli, and Jorma Keski-Oja

5 Regulators of Smad2/3 Transcription and Phosphorylation
Azeddine Atfi* and Marie-Francoise Bourgeade

6 Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in Hyperplasia, Neoplasia, and Tumor Progression
Sang Soo Kim, Charles Shuman, and Lopa Mishra*

7 Regulation of Smad Activity by Phosphorylation
Fang Liu*

8 Nuclear Targeting of TGF-ß-activated Smads in Normal and Tumor Biology
Lan Xu*

9 Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival
Erwan Le Scolan and Kunxin Luo*

10 Smurfs in TGF-ß Signaling and Regulation of Bone Homeostasis and Cancer
Ying E. Zhang* and Motozo Yamashita

11 Involvement of KM23 Dynein Light Chains in TGF-ß Signaling
Qunyan Jin, Guofeng Gao, and Kathleen M. Mulder*

12 TGF-ß Signaling in Fibroblastic Cells and Oncogenes
Neil A. Bhowmick*

13 Mechanisms of TGF-ß-induced Apoptosis in Cancer Cells
Tae-Aug Kim* and Seong-Jin Kim

14 Mechanisms of Cell Cycle Regulation by TGF-ß Disabled in Cancer
Leslie I. Gold* and Jon Lecanda

15 Proteasome in the Control of TGF-ß Signaling During Development and Cancer
Arja Band and Marikki Laiho*

16 TGF-ß and Smad Signaling in Transcriptome Reprogramming During Epithelial to Mesenchymal Transition
Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, and Aristidis Moustakas*

17 Functional Interaction between MMPs and TGF-ß in Normal and Tumor Tissue
Christina H. Stuelten*, Anita B. Roberts, and William G. Stetler-Stevenson

18 Cooperation Between TGF-ß and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function
Irwin M. Liu, Steven H. Schilling, and Xiao-Fan Wang*

19 Interaction of Oncogenic Ras and TGF-ß1 Signaling in Cancer: Lessons from the Multistage Skin Carcinogenesis Model
Adam Glick*, Dong-Soon Bae, Xin Liu, and Kinnimulki Vijayachandra

Part II. TGF-ß Superfamily Members in Normal and Tumor Biology

20 Proteomics Analysis of TGFß Superfamily Members
Serhiy Souchelnytskyi*

21 Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers
David T. MacLaughlin* and Patricia K. Donahoe

22 Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of Prostate Cancer Progression Tetsu Hayashida, Vandana Gupta, Sam Thiagalinam, and Shyamala Maheswaran*

23 Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
George Berberian, Deepak Malhotra, and John E. Langenfeld*

24 Histone Methyltransferase and Smad Interactions in BMP Signaling
Jennifer E. Leader, M. Pilar Frontelo, and Robert J. Lechleider*

25 Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies
Ester Fonsatti and Michelle Maio*

26 Activins and Inhibins in Cancer Progression
Gail P. Risbridger* and Christopher Butler

27 Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Granulosa Cells and Carcinoma
Sabine Mazerbourg*

28 Regulation of the TGF-ß Superfamily by Betaglycan
Fernando López-Casillas*, M. Magdalena Vilchis-Landeros, José Esparza-López, M. Verónica
Ponce-Castaneda, N. Gabriela Velasco-Loyden, Patricia Juarez, Jose Luis Montiel, and Valentín Mendoza

29 Uterine Sensitization Associated Gene-1 (USAG): A Bone Morphogenic Protein Antagonist with a Role in Kidney
Motoko Yanagita*

30 Role of Betaig-h3 Gene in Carcinogenesis
Yongliang Zhao* and Tom K. Hei

31 Activins and the Liver
Michael Grusch, Chantal Rodgarkia-Dara, Wilfried Bursch, and Rolf Schulte-Hermann*

32 Myostatin Signaling in Normal and Tumor Cells
Xiangyang Zhu*, Li-fang Liang, and Ronald L. Stotish

Part III. TGF-ß in Inflammation and Fibrosis

33 Triterpenoids, Vitamin D, and TGF-ß/Smad Signaling in Inflammation and Cancer
Nanjoo Suh*

34 Thrombospondin-dependent Activation of Latent TGF-ß in Fibrosis and Disease
Joanne E. Murphy-Ullrich*

35 TGF-ß1 in Pulmonary Fibrosis
Masahito Ebina*

36 The Role of TGF-beta in Bleomycin Induced Pulmonary Fibrosis
Nasreen Khalil* and Robert O'Connor

37 Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse
Kathleen C. Flanders*

38 TGF-ß Signaling in Renal Fibrosis and Inflammation: Gene Therapy using Ultrasound-Microbubble
-mediated Inducible Smad7
Hui Y. Lan*

39 Transforming Growth Facator-ß Peptide Signaling in Pulmonary Development, Bronchopulmonary
Dysplasia, Fibrosis, and Emphysema
David Warburton*, Wei Shi, Martin Kolb, and Jack Gauldie

40 The Role of TGF-ß in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-ß as
a Novel Therapeutic Strategy
Patricia J. Sime*, R. Matthew Kottmann, Heather F. Lakatos, and Thomas H. Thatcher

41 Negative Regulation of the TGF-ßFamily Signaling Pathway by Inhibitory Smads and Their Involvement
in Cancer and Fibrosis
Susumu Itoh*, Hiroyuki Suzuki, Fumiko Itoh, Kohei Miyazono, and Mitsuyasu Kato

42 TGF-ß-Related Antifibrotic Strategies in the Eye
M. Francesca Cordeiro*, Annelie Maass, Clive Migdal, and Li Guo

43 TGF-ß in Cutaneous Tissue Repair
Jisun Cha and Vincent Falanga*

44 Topical Application of TGF-ß1 Peptide Inhibitors for the Therapy of Skin Fibrosis
Javier Dotor and José L. Pablos*

45 Overexpressed Truncated TGF-ß Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In
Vitro and Experimental Scar Formation In Vivo
Wei Liu*, Chekhau Chua, Zhen Gao, Xiaoli Wu, and Yilin Cao