Genomics in Endocrinology: Dna Microarray Analysis in Endocrine Health and Disease

Description

• Focuses on exciting new advances in endocrinology
• Includes a comprehensive introduction to the use of DNA microarrays in endocrinology
• Chapters on genome characterizations of endocrine-producing tissues

In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volume’s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of

1. genomic insights into molecular mechanisms responsible for hormone action,
2. genomic characterizations of endocrine producing tissues, and
3. genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

Table of Contents

Introduction

• Chapter 1: Microarray-based Gene Expression Analysis of Endocrine Systems: Principles of Experimental Design and Interpretation
  Jegga, Anil G., Bruce J Aronow, Stuart Handwerger

Hormone Action and Molecular Mechanisms

• Chapter 2: Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblastic Cells
  Gene Ling Qin, Ping Qui, Nicola C. Partridge
• Chapter 3: Analysis of Growth Hormone effects on hepatic gene expression in hypophysectomized rats.
  Amilcar Flores-Morales and Leandro Fernandez-Perez
• Chapter 4: Gene expression profiling in leiomyoma in response to GnRH therapy and TGF-b
  Nasser Chegini and Xiaoping Luo
• Chapter 5: Gene Profiling Analysis of Androgen Receptor Mediated Function
  Comstock, Clay E.S.,Craig J. Burd, Walter J. Jessen, Karen E. Knudsen
• Chapter 6: Interrogating Estrogen Receptor Signaling in Breast Cancer by Chromatin Immunoprecipitation Microarrays
  Cheng, Alfred S.L., Huey-Jen Lin, and Tim H.-M. Huang
• Chapter 7: Gene expression analysis of adrenal cortex in health and disease
  Anelia Horvath and Constantine A. Stratakis

Endocrine Producing Tissues

• Chapter 8: DNA microarray analysis of decidualization
  Ori Eyal, MD and Stuart Handwerger, MD
• Chapter 9: Large scale DNA Microarray data analysis reveals glucocorticoid receptor-mediated breast cancer cell survival pathways
  Min Zou, Wei Wu, and Suzanne D. Conzen
• Chapter 10: Application of Microarrays for gene transcript analysis in type 2 diabetes
  R. Sreekumar, C. P. Kolbert, Y. Asmann, and K.S.Nair
• Chapter 11: DNA Microarray Analysis and Effects of TSH, Iodide, Cytokines and Therapeutic Agents on Gene Expression in Cultured Human Thyroid Follicles
  Kanji Sato, Kazuko Yamazaki, Emiko Yamada

Diseases of Hormonal Systems

• Chapter 12: Genomics and Polycystic Ovary Syndrome (PCOS): the Use of Microarray Analysis to Identify New Candidate Genes
  Jennifer R. Wood, PhD and Jerome F. Strauss, III MD, PhD
• Chapter 13: Microarray Analysis of Alterations Induced by Obesity in White Adipose Tissue Gene Expression Profiling
  Julien Tirard, Ricardo Moraes, Danielle Naville, and Martine Begeot
• Chapter 14: Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction
  Chheng-Orn Evans, Carlos S. Moreno, Nelson M. Oyesiku
• Chapter 15: Gene Expression Studies of Prostate Hyperplasia in Prolactin Transgenic Mice
  Karin Dillner PhD, Jon Kindlom MD, PhD, Amilcar Flores-Morales PhD, and Hagan Wennbo MD, PhD