Cardiovascular Genomics

This book covers the entire spectrum of cardiovascular genomics. It is organized into three parts: Genes and Polymorphisms in Cardiovascular Disease; Gene Transfer for Cardiovascular Disease; and Regenerative Tissues for the Diseased Cardiovascular System. Leading clinical researchers provide an updated account of the most recent molecular approaches utilized to understand the cardiovascular system in both health and disease. It provides and excellent resource for students, researchers and clinicians on the potential of developing novel strategies for the control of cardiovascular disease.

Contents: Part I. Genes and Polymorphisms in Cardiovascular Disease Angiotensin II Receptor Polymorphisms and Hypertension Bruno Baudin Angiotensinogen Gene Polymorphisms and Hypertension Ashok Kumar Substitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood Pressure Bina Joe and Michael R. Garrett Local Production of Angiotensinogen: Insights from Genetic Manipulation of Mice Kamal Rahmouni and Curt D. Sigmund Cardiovascular Pharmacogenomics Julie A. Johnson and Larisa H. Cavallari Genetic Polymorphisms and Responses to HMG-CoA, Reductase Inhibitors Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boer Monogenic Causes of Heart Failure: Familial Dilated Cardiomyopathy Hideko Kasahara Part II. Gene Transfer for Combating Cardiovascular Disease Gene Therapy vs. Pharmacotherapy Ryuichi Morishita Molecular Therapeutic Approaches for Myocardial Protection Alok S. Pachori, Luis G. Melo, and Victor J. Dzau Gene Transfer and the Cardiovascular System William H. Miller, Stuart A. Nicklin, Andrew H. Baker, and Anna F. Dominiczak Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke Julie Chao and Lee Chao Current and Future Novel Targets of Gene Therapy for Hypertension Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizada Application of Viral Gene Transfer in Studies of Neurogenic Hypertension Sergey Kasparov, A. G. Teschemacher, and Julian F. R. Paton Vigilant Vectors: Intelligent Gene Vectors for Cardio-Protection in Myocardial Ischemia M. Ian Phillips and Yi Tang Gene Therapy for Cerebral Arterial Diseases Yoshimasa Watanabe and Donald D. Heistad Part III. Regenerative Tissues for the Diseased Cardiovascular System Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration Paolo Madeddu Cell Transplantation: The New Frontier Shafie Fazel, Paul W. M. Fedak, Richard D. Weisel, Denis Angoulvant, Terrence M. Yau, and Ren-Ke Li Embryonic Stem Cells and the Cardiovascular System Neta Lavon and Nissim Benvenisty