Ototoxicity

Ototoxicity is a compendium of information on the ototoxic potential of clinically useful drugs. Each section of this thorough text is written by a leading authority in the field. The book reviews the important classes of medications known to cause ototoxicity and their mechanisms. Clinical manifestations, what is known about pathophysiology, strategies for prevention and treatment, and medical-legal issues for each class of compounds are reviewed. Auditory and vestibular monitoring and new therapeutic strategies that may prevent or minimize ototoxicity are highlighted in addition to discussing recent advances in protective therapy. Also included is the therapeutic use of the ototoxic properties of aminoglycosides in the clinical treatment of inner ear dysfunction.

Features

• Presents a thorough discussion of the ototoxic potential of clinically useful drugs
• Examines clinical manifestations, pathophysiology, prevention, treatment, and medical-legal issues
• Features the contributions of leading authorities in the field

Contents

Preface

Section I: Anatomy and Physiology

1. Anatomy and Physiology of the Cochlea
Karen S. Pawlowski, PhD
2. Anatomy and Physiology of the Vestibular System

John A. Rutka, MD, FRCSC

Section II: Systemic Toxicity

3. Salicylates, Nonsteroidal Anti-inflammatory Drugs, Quinine, and Heavy Metals

Narayanan Prepageran, MD, FRCS, John A. Rutka, MD, FRCSC

4. Loop Diuretics
Narayanan Prepageran, MD, FRCS, Andrew R.Scott, BM, BS, MPhil, FRCS (ORL-HNS), John A. Rutka, MD, FRCSC
5. Cinical Uses of Cisplatin

Jeremy Sturgeon, MD, FRCPC

6. Platinum Compounds
Michael Anne Gratton, PhD
7. Iron Chelating and Other Chemotherapeutic Agents: The Vinca Alkaloids
Andrew R.Scott, BM, BS, MPhil, FRCS(ORL-HNS), Narayanan Prepageran, MD, FRCS, John A. Rutka, MD, FRCSC
8. Clinical Aminoglycoside Ototoxicity
Coleman Rotstein, MD, FRCPC, Lionel A. Mandell, MD, FRCPC, FRCP (Lond)
9. Mechanisms for Aminoglycoside Toxicity: Basic Science Research

Jochen Schacht, PhD

10. Macrolides
Andrew R. Scott, BM, BS, MPhil, FRCS(ORL-HNS), John A. Rutka, MD, FRCSC

Section III: Topical Toxicity

11. Middle Ear Effects of Ototopical Agents
Charles G. Wright, PhD, Peter S. Roland, MD
12. Topical Aminoglycoside Cochlear Toxicity
Peter S. Roland, MD, Charles G. Wright, PhD
13. Topical Aminoglycoside Vestibular Toxicity
Narayanan Prepageran, MD, FRCS, Vitaly E. Kisilevsky, MD, John A. Rutka, MD, FRCSC
14. Chloramphenical, Colymyxin, and Polymyxin
Leonard P. Rybak, MD, PhD, Srinivasan Krishna, MD, MPH
15. Topical Antifungals
Lawrence W. C. Tom, MD, Lisa M. Elden, MS, MD, Roger R. Marsh, PhD
16. Surgical Disinfectants and Antiseptics
Andrew R. Scott, BM, BS, MPhil, FRCS(ORL-HNS), Narayanan Prepageran, MD, FRCS, John A. Rutka, MD, FRCSC

Section IV: Interventions

17. Genetic Factors in Aminoglycoside Ototoxicity
Nathan Fischel-Ghodsian, MD
18. Audiologic Monitoring for Ototoxicity
Kathleen C. M. Campbell, PhD
19. Monitoring Vestibular Ototoxicity
Vitaly E. Kisilevsky, MD, David Tomlinson, PhD, Paul Ranalli, MD, FRCPC, Narayanan Prepageran, MD, FRCS
20. Treatment, Prevention, and Neural Regeneration
Thomas R. Van De Water, MD, and Leonard P Rybak, MD, PhD

Section V: Therapeutic Uses of Ototoxic Effects

21. Systemic Treatment of Bilateral Meniere's Disease
Sumit K. Agrawal, MD, and Lorne S. Parnes, MD, FRCSC
22. Intratympanic Gentamicin in the Treatment of Meniere's Disease
Brian W. Blakley, MD, PhD, FRCSC
Section VI: Medicolegal Concerns
23. Medicolegal Concerns
Peter E. Rhatican, JD, Sloan H. Mandell, LLB, and John A. Rutka, MD, FRCSC