The Blood-Brain Barrier in Health and Disease, Vol. 2: Pathophysiology and Pathology

Description

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs.

In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases.

This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Features

• Demonstrates that the blood-brain barrier is a dynamic permeability barrier that both protects the internal milieu of the brain and allows essential nutrients to be transported into the brain
• Describes how abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs
• Presents comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases

Table of Contents

Blood-Brain Barrier Disruption in Multiple Sclerosis. Portals of Viral Entry into the Central Nervous System. Blood-Brain Barrier Dysfunction in HIV Infection. The Brain Microvasculature in Cerebral Malaria. The Blood-Brain Barrier in Bacterial Infections of the Central Nervous System. The Blood-Brain Barrier in Fungal Infections of the Central Nervous System. Blood-Brain Barrier Changes in Traumatic Brain Injury. Alterations of the Blood-Brain Barrier in Post-Traumatic Epilepsy. Functional and Molecular Mechanisms of Hypertensive Brain Damage. Blood-Brain Barrier Protection in Stroke: Taming tPA. Radiation-induced Blood-Brain Barrier Disruption. Alterations of the Blood-Brain Barrier in Thiamine Deficiency. The Blood-Brain Barrier in Brain Tumors. Cerebral Amyloid Angiopathy. The Blood-Brain Barrier in Neurodegenerative Diseases. Alterations of Blood-Brain Barrier Function by Drugs of Abuse.