Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine

Description

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery.

This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Features

• Reviews emerging "lab-on-a-chip" miniaturization technologies
• Covers micro-fabrication, 3D bio-printing and cell culture techniques, biosensor design and other technologies
• Includes special focus on "organs-on-a-chip" and "cancer-on-a-chip" technologies
• Summarizes special applications such as personalized medicine and detecting pathogens

Contents

Introduction

Microfabrication and 3-D Bioprinting of Organs-on-a-Chip
Prafulla Chandra, Carlos Kengla, Sang Jin Lee

Three-Dimensional Cell Culture
Ivy L. Mead, Colin E. Bishop

Electrochemical Sensors for Organs-on-a-Chip
Joyce Han-Ching Chiu, Ge-Ah Kim, Rodney Daniels

Microfluidics
Panupong Jaipan, Roger Narayan

From Big Data to Predictive Analysis from in vitro Systems
Andre Kleensang, Alexandra Maertens, Thomas Hartung

Lab-on-a-Chip Systems for Biomedical Applications
Peter Ertl

From 2D Culture to 3D Microchip Models: Trachea, Bronchi/bronchiole and Lung Biomimetic Models for Disease Modeling, Drug Discovery and Personalized Medicine
Joan E. Nichols,Stephanie P. Vega,Lissenya B. Argueta, Jean A. Niles, Michael Smith, Adrienne Eastaway, David Brown, Joaquin Cortiella

Liver and Liver Cancer-on-a-Chip
Aleksander Skardal

Heart-on-a-Chip
Megan L. McCain

Skin-on-a-Chip
Claire G. Jeong

Tissue Engineered Kidney Models
Erica P. Kimmerling, David L. Kaplan

Body-on-a-Chip
Mahesh Devarasetty, Steven D. Forsythe,Thomas D. Shupe, Aleksander Skardal, Shay Soker

Integrated Multi-Organoid Dynamics
Ran Li, Michelle B. Chen, Roger D. Kamm

Cancer Metastasis-on-a-Chip
Ran Li, Michelle B. Chen, Roger D. Kamm

Breast Cancer-on-a-Chip
Pierre-Alexandre Vidi, Sophie A. Lelièvre

Disease Modeling
Harry SalemUta Grieshammer, Kelly A. Shepard

In Vivo, In Vitro And Stem Cell Technologies To Predict Human Pharmacology and Toxicology
Harry Salem

Personalized Medicine
Elisa Cimetta, Michael Lamprecht, Sarindr Bhumiratana,Nafissa Yakubova,Nina Tandon