Principles and Practice of Transplant Infectious Diseases

Chapter 1
Infections in Transplantation: Introduction and Overview
Amar Safdar

Chapter 2
Infections in Heart, Lung, and Heart-Lung Transplantation
Andres F. Henao-Martinez and Jose G. Montoya

Chapter 3
Infections in Liver Transplantation
B. Sharmila Mohanraj, Amol S. Rangnekar, and Joseph G. Timpone, Jr

Chapter 4
Infections in Kidney and Pancreas Transplantation
Megan K. Morales, Matthew Cooper, Peter Abrams, and Joseph G. Timpone, Jr

Chapter 5
Infections in Intestinal and Multivisceral Transplantation
Raffaele Girlanda, Joseph G. Timpone, Jr, Kevin M. Soriano, and Thomas M. Fishbein

Chapter 6
Infections in Limbs, Integuments, and Face Transplantation
Justin M. Broyles and Chad R. Gordon

Chapter 7
Principles of Hematopoietic Stem Cell Transplantation
Michelle Limei Poon, Richard E. Champlin, and Partow Kebriaei

Chapter 8
Infections in Pediatric Transplant Recipients
Aspasia Katragkou, Lucy O'Connor, Emmanuel Roilides, and Thomas J. Walsh

Chapter 9
Febrile Neutropenia in Transplant Recipients
Lior Nesher and Kenneth V. I. Rolston

Chapter 10
Cytopenias in Transplant Patients
Maura Barry, Sunandana Chandra, and Kenneth B. Hymes

Chapter 11
Infections in Allogeneic Stem Cell Transplantation
Marcus R. Pereira, Stephanie M. Pouch, and Brian Scully

Chapter 12
Complications Arising from Preparatory Conditioning Regimens for Stem Cell Transplantation
Jasmine Zain and Merav Bar

Chapter 13
Intravascular Catheter and Implantable Device Infections in Transplant Patients
Nasia Safdar, Cybele Lara R. Abad, and Dennis G. Maki

Chapter 14
Surgical Site Infections: Wound and Stump Infections
Nasia Safdar, Sara A. M. Zerbel, and Elizabeth Ann Misch

Chapter 15
Endovascular Infections and Endocarditis
Walter Zingg and Didier Pittet

Chapter 16
Gastrointestinal Infections and Clostridium difficile Infection
Stephen Harold and Herbert L. DuPont

Chapter 17
Hepatobiliary Tract Infections
Jonathan Merola, Robert M. Mocharla, Alexander Z. Jow, Samuel H. Sigal, and Amar Safdar

Chapter 18

Ocular Infections in Transplant Patients
Ann-Marie Lobo, Lucia Sobrin, and Marlene L. Durand

Chapter 19
Intracranial, Spinal, and Paraspinal Infections in the Transplant Recipient
Matthew W. McCarthy, Axel Rosengart and Thomas J. Walsh

Chapter 20
Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia
Benjamin A. Miko, Marcus R. Pereira, and Amar Safdar

Chapter 21
Respiratory Tract Diseases That May Be Mistaken For Infection
Robert M. Kotloff, Burton F. Dickey, and Nicholas Vander Els

Chapter 22
Skin and Soft Tissue Infection in Transplant Recipients
Robert G. Micheletti and Carrie L. Kovarik

Chapter 23
Cutaneous Lesions that Mimic Infection in Transplant Patients
Ana Ciurea and Sharon Hymes

Chapter 24
Staphylococcus, Streptococcus, and Enterococcus
Amar Safdar and Donald Armstrong

Chapter 25
Enterobacteriaceae in Transplantation
Kathryn Whitaker, Valerie Cluzet, and Emily A. Blumberg

Chapter 26
Pseudomonas, Stenotrophomonas, Acinetobacter, and Other Non-Fermentative Gram-Negative Bacteria & Medically Important Anaerobic Bacteria in Transplant Recipients
Kenneth V.I. Rolston and Amar Safdar

Chapter 27
Nocardiosis and Actinomycosis
Heather E. Clauss and Bennett Lorber

Chapter 28
Listeriosis
Heather E. Clauss and Bennett Lorber

Chapter 29
Tuberculosis
Cynthia Portal-Celhay and Jennifer A. Philips

Chapter 30
Nontuberculous Mycobacterial Disease in Transplant Recipients
Julie V. Philley, Amar Safdar, and Charles L. Daley

Chapter 31
Invasive Fungal Disease in the Transplant Population: An Overview
Jennifer L. Saullo, John R. Perfect, and Barbara D. Alexander

Chapter 32
Candida Infections in Hematopoietic and Solid Organ Transplant Recipients
Alison G. Freifeld and Carol A. Kauffman

Chapter 33
Aspergillosis
Michael J. Satlin, Samantha E. Jacobs, and Thomas J. Walsh

Chapter 34
Mucormycosis
Brad Spellberg and Johan Maertens

Chapter 35
Cryptococcus Infections in Transplant Recipients
Raymund R. Razonable and Pearlie P. Chong

Chapter 36
Histoplasmosis, Coccidioidomycosis and Diseases due to Other Endemic Fungi in Transplant Recipients
Pascalis Vergidis, Chadi A. Hage, and L. Joseph Wheat

Chapter 37
Cytomegalovirus
Amar Safdar and Donald Armstrong

Chapter 38
Epstein-Barr Virus Infection and Post-Transplant Lymphoproliferative Disease
Benjamin E. Gewurz, Amy Sievers, David M.Weinstock, Sheila Mitsuma and Amar Safdar

Chapter 39
Herpes Simplex Viruses 1 and 2, Varicella Zoster Virus and Human Herpes Viruses 6, 7 and 8 in Transplant Recipients
Raymund R. Razonable*

Chapter 40
Respiratory Viral Infections in Transplant Recipients
Catherine Liu, Dora Y. Ho, and Michael Boeckh

Chapter 41
Hepatitis A, B, C
Jonathan Merola, Alexander Z. Jow, and Samuel H. Sigal

Chapter 42
Enterovirus Infection in Immunocompromised Hosts
Joanna Schaenman, Dora Y. Ho, Lindsey R. Baden, and Amar Safdar

Chapter 43
Parvovirus B19
Morgan Hakki and Lynne Strasfeld

Chapter 44
West Nile Virus in Immunocompromised Hosts
Dora Y. Ho, Joanna M.D. Schaenman, and Lindsey R. Baden

Chapter 45
Rare and Emerging Viral Infections in the Transplant Population
Susanna K. Tan, Jesse J. Waggoner, and Stan Deresinski

Chapter 46
Parasitic Infections in Transplant Recipients: Toxoplasmosis, Strongyloidiasis and Other Parasites
Brian G. Blackburn and Jose G. Montoya

Chapter 47
Impacts and Challenges of Advanced Diagnostic Assays for Transplant Infectious Diseases
N. Esther Babady, Yeon Joo Lee, Genovefa Papanicolaou, and Yi-Wei Tang

Chapter 48
Diagnosis of Systemic Fungal Diseases
Simon F. Dufresne, Kieren A. Marr and Shmuel Shoham

Chapter 49
Viral Diagnostics
Robin K. Avery and Belinda Yen-Lieberman

Chapter 50
Antibiotic Consideration in Transplant Recipients
Jerry Altshuler, Samuel L. Aitken, Melanie Maslow, John Papadopoulos, and Amar Safdar

Chapter 51
Pharmacokinetics and Pharmacodynamics of Antibiotics in Transplant Patients
Kelly E. Schoeppler, Scott W. Mueller, and Gerard R. Barber

Chapter 52
Antifungal Consideration for Transplant Recipients
Yanina Dubrovskaya, Man Yee Merl, David S. Perlin, and Amar Safdar

Chapter 53
Immunomodulatory Properties of Antifungal Agents on Immune Functions of the Host
Maria Simitsopoulou and Emmanuel Roilides

Chapter 54
Antiviral Consideration for Transplantation Including Drug Resistance
Sunwen Chou and Nell S. Lurain

Chapter 55
Pharmacokinetics and Pharmacodynamics of Antiviral Drugs in Special Population
Marco R. Scipione* and John Papadopoulos

Chapter 56
Anti-Mycobacterial Consideration in Transplantation Including Drug Non-Susceptibility and Resistance: Tuberculosis and Nontuberculous Mycobacterial Disease
Julie V. Philley and David E. Griffith

Chapter 57
Adaptive Immunotherapy for Opportunistic Infections
Aspasia Katragkou, Thomas J. Walsh, and Emmanuel Roilides

Chapter 58
Immunotherapy for Invasive Mold Disease in Transplant Patients - Dendritic Cell Immunotherapy, Interferon-gamma, Recombinant Myeloid Growth Factors, and Healthy Donor Granulocyte Transfusions
William K. Decker, Matthew M. Halpert, Vanaja Konduri, Dan Liang, Christopher N. Hampton, and Amar Safdar

Chapter 59
Antimicrobial Stewardship: Considerations for a Transplant Center
Susan K. Seo and Graeme N. Forrest

Chapter 60
The Use of Palliative Care in Organ Transplant Patients and End of Life Issues
Jenny S. Ayala and Joseph Lowy

Chapter 61
Infection Control Strategies in Transplant Populations
Scott Cutro, Michael Phillips, and Harold W. Horowitz

Chapter 62
Travel and Transplantation
Camille Nelson Kotton and Jose G. Montoya

Chapter 63

Vaccination in Organ Transplant
Lara Danziger-Isakov and Camille Nelson Kotton

Chapter 64
Prevention of Fungal Disease
Shirish Huprikar and John R. Wingard

Chapter 65
Antimicrobial Drug Prophylaxis: Challenges and Controversies
Gaurav Trikha, Marcio Nucci, John R. Wingard and Amar Safdar

This comprehensive volume provides a platform from which both major and minor infectious diseases related issues are addressed in-depth among this highly susceptible population. The book begins with an overview of infections in various modalities. This is followed by chapters on clinical disorders, etiologic agents, therapeutics, and infection prevention. Chapters include easy-to-follow figures and tables, radiologic images, and pictorial demonstrations of various disease states to familiarize and reacquaint the transplant clinicians and surgeons in practice and training, and those belonging to subspecialties providing supportive care for these patients. Discussions to enumerate the noninfectious causes that mimic infectious diseases; clinical relevance and effective utility of existing and emerging diagnostic tools are presented throughout the book. Authored by leaders in their fields, this book is the go-to reference for management of patients undergoing hematopoietic and solid organ transplantation.

Amar Safdar, MD
Clinical Associate Professor of Medicine
Texas Tech University Health Sciences Center El Paso
Paul L. Foster School of Medicine
El Paso, TX, USA