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Studies on the Cornea and Lens
Li, D.W.-C. — Alió, J.L. — Kasus-Jacobi, A. — Žorić, L. — Babizhayev, M.A.
1ª Edición Enero 2015
Inglés
Tapa dura
447 pags
2200 gr
21 x 27 x null cm
ISBN 9781493919345
Editorial SPRINGER
Description
This comprehensive volume presentsdata describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discusstopics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised offour chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group.
Studies on the Cornea and Lens is an essential addition to the library or department of physicians and researchers who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. ?This book is an authoritative contribution to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series.
Contents
1 Oxidative Stress in Cornea
2 Corneal Degenerations
3 Corneal Epithelial Nuclear Ferritin and its Transporter Ferritoid Afford Unique Protection to DNA from U.V. Light and Reactive Oxygen Species
4 Excitatory Amino Acid Transporters, Xc- Antiporter, g-Glutamyl Transpeptidase, Glutamine Synthetase Activity and Glutathione in Human Corneal Epithelial Cells
5 Transforming Growth Factor – ß3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts
6 Corneal Stem Cells: a Source of Cell Renewal with Therapeutic Potential
7 New Agents for Treating Dry Eye Syndrome
8 Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells
9 Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis
10 The Human Lens: A living Biometric Indicator of Health Status and Successful Aging
11 Oxidative Stress in Lens
12 Protein Serine/Threonine Phosphatases-1 and –2A in Lens Development and Pathogenesis
13 Proteases in Lens and Cataract
14 Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System
15 p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation
16 Etiology and Prevention of Cataract
17 The Effects of Lutein in Preventing Cataract Progression
18 Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts
19 Updates and Advances in Corneal Surgery
20 Cataract and Diabetic Retinopathy
21 Traumatic Cataract-a Review
22 Cataract in Paediatric Age Group-a Review.
Authors
Dr. Mark Babizhayev is a bio-physicist and holds a PhD in Biophysics and Pathophysiology
from the Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia.
He has dedicated many years to scientific research and has written more than
102 published articles and has fifteen patents to his name. The recipient of
numerous awards, Dr. Babizhayev is currently Executive Director of Innovative
Vision Products, Inc., Delaware, USA, Senior Research Investigator at Moscow
Helmholtz Research Institute of Eye Diseases, and Scientific Consultant at EXSYMOL
SAM, Monte Carlo, Monaco, and Bruschettini SRL, Genoa, Italy. He is also one
of the principal researchers involved in the development of a breakthrough for
the treatment and prevention of senile cataract.
Dr. David Wan-Cheng Li is an Associate Professor of Ophthalmology and Visual
Sciences in the Truhlsen Eye Institute, University of Nebraska Medical Center,
Omaha,an elected Lotus Scholar Professor of Cell and Developmental Biology of
China's Hunan Normal University by Hunan Province Government, and a Visiting
Professor of Ophthalmology and Visual Sciences in the State Key Laboratory in
the Zhongshan Ophthalmic Center of Sun Yat-Sen University Medical Center, Guangzhou,China.
He received his PhD from University of Washington, Seattle, USA, and completed
his postdoctoral training at Columbia University, New York, USA. His scientific
contributions include the major discoveries that stress-induced apoptosis acts
as a common cellular mechanism for non-congenital cataract formation, that human
hTERT is compatible with the RNA template from bovine and rabbit, and that different
SUMOs have distinct functions in regulating cell differentiation. He received
the outstanding cataract research award from National Foundation for Eye Research
and the Lotus Scholar Contribution Award from Hunan Province Government. He
is currently the Editor-in-Chief for Current Molecular Medicine.
Dr. Anne Kasus-Jacobi is Assistant Professor of Pharmaceutical Sciences and
adjunct faculty in the Departments of Neuroscience and Physiology at the University
of Oklahoma Health Sciences Center, Oklahoma City,USA. She was previously Assistant
Professor of Ophthalmology at the Dean McGee Eye Institute in the University
of Oklahoma Health Sciences Center. She received her PhD in Endocrinology from
the University of Paris, France, and continued her postdoctoral training in
the laboratory of Drs. Michael Brown and Joseph Goldstein at the University
of Texas Southwestern Medical Center, Dallas, USA. Dr. Kasus-Jacobi’s
current interests include the development of innovative peptide treatments for
corneal wounds and antibiotic-resistant bacterial infections. She is a member
of the Association for Research in Vision and Ophthalmology and serves as an
editorial board member of the Journal of Ocular Diseases and Therapeutics.
Dr. Lepša oric works in clinical ophthalmology on the Faculty of
Medicine of University of Pristina, Serbia. She completed her PhD at the University
of Pristina with a thesis on anti-oxidation status in aqueous humour, lens and
serum of patients with age-related cataracts. A member of several international
and national medical and neuro-ophthalmology societies, Dr. Zoric has presented
or published more than 100 articles in both domestic and international journals.
Dr. Jorge L. Alió is Professor and Chairman of Ophthalmology at the Miguel
Hernández University, Alicante, Spain, and formerly chairman of Ophthalmology
at the University of Alicante, Spain. He has been appointed with several visiting
professorships at universities in the United States and Europe. He attended
the Complutense University of Madrid, Spain, where he received a medical degree
and a PhD in biological thermodynamics and its application in the study of ophthalmic
pathology. Recipient of the 2012 Lifetime Achievement Award from the International
Society of Refractive Surgery, Dr. Alió’s main research interests
include refractive, lens and corneal surgery, ocular inflammation and preventative
ophthalmology. His main contributions have been in the area of excimer laser
refractive surgery, microincisional lens surgery, and multifocal accommodative
and premium IOLs.
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