Molecular Testing in Cancer

ABOUT THIS BOOK

· Written by experts in this field
· Illustrated with high quality color microphotographs
· Formatted for ease of use in the lab

Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers.

Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.

Content Level » Professional/practitioner
Keywords » Epigenetics - PCR - Proteomics - methylation analysis - tumor markers
Related subjects » Biomedical Sciences - Cancer Research - Internal Medicine - Pathology

TABLE OF CONTENTS

Part 1: Molecular approaches and techniques

Chapter 1: Transitioning Diagnostic Molecular Pathology to the Genomic Era: Cancer Somatic Mutation Panel Testing
Kitchener D. Wilson and Iris Schrijver

Chapter 2: Conventional and Molecular Cytogenetics in Cancer
Michelle Dolan

Chapter 3: Comparative Genomic Hybridization and Array based CGH in Cancer
Roland Hubaux, Victor D. Martinez, David Rowbotham, and Wan L. Lam

Chapter 4: Polymerase Chain Reaction
Maria Pasic, Carlo Hojilia, and George M. Yousef

Chapter 5: Single Nucleotide Polymorphisms (SNPs)
Jyotsna Batra, Srilakshmi Srinivasan, and Judith Clements

Chapter 6: Clinical Application of DNA Sequencing: Sanger and Next-Generation Platforms
John D. McPherson

Chapter 7: Microarray-based Investigations in Cancer
Maud H.W. Starmans, Syed Haider, Cindy Yao, Philippe Lambin, and Paul C. Boutros

Chapter 8: Proteomics in Cancer Diagnostics
Kevin P. Conlon, Delphine Rolland, Kojo S. J. Elenitoba-Johnson

Chapter 9: Circulating Tumor Cells: A Non-Invasive Liquid Biopsy in Cancer
Evi S. Lianidou

Part 2: Molecular applications in various malignancies

Chapter 10: Molecular Testing in Hematological Malignancies
Amir Behdad, Bryan L. Betz, Megan S. Lim, and Nathanael G. Bailey

Chapter 11: Molecular Testing in Breast Cancer
Dimitrios Zardavas, Debora Fumagalli, and Christos Sotiriou

Chapter 12: Molecular Pathology of Gastrointestinal Tumors
Andrea Grin and Serge Jothy

Chapter 13: Molecular Testing in Pulmonary Tumors
Jeffrey J. Tanguay, Shirin Karimi, David M. Hwang, and Ming-Sound Tsao

Chapter 14: Molecular testing in Gynecological Malignancies
Pamela M. Ward and Louis Dubeau

Chapter 15: Molecular Testing in Central Nervous System tumors
Jason Karamchandani

Chapter 16: Molecular Testing in Adult Kidney Tumors
Manal Y. Gabril and George M. Yousef

Chapter 17: Molecular Testing in Prostate Cancer
Manal Y Gabril and George M Yousef

Chapter 18: Molecular Testing in Urothelial Tumors
Manal Y Gabril and George M Yousef

Chapter 19: Molecular Testing in Thyroid Cancer
Matthew T. Olson, Jason D. Prescott, and Martha A. Zeiger

Chapter 20: Molecular Testing of Head and Neck Tumors
Diana Bell and Ehab Y. Hanna

Chapter 21: Molecular Testing in Bone and Soft Tissue Tumors
Brendan C. Dickson, Gino R. Somers, Rita A. Kandel

Chapter 22: Molecular testing in Cutaneous Melanoma
Margaret Redpath, Leon van Kempen, Caroline Robert, and Alan Spatz

Chapter 23: Molecular Testing in Pediatric Tumors
Gino R. Somers and Paul S. Thorner

Chapter 24: Pharmacogenomics in Molecular Oncology
Gregory J. Tsongalis

Chapter 25: Quality Assurance in Molecular Testing of Cancer
Sylviane Olschwang, Simon Patton, Etienne Rouleau, and Elisabeth Dequeker

AUTHORS & EDITORS

George M. Yousef, MD, PhD
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada

Serge Jothy, MD, PhD
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada