Intraperitoneal Cancer Therapy. Principles and Practice

Description

Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy.

The book covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments.

The book is a state-of-the-art reference for surgical and medical oncologists interested in the treatment of carcinomatosis. It also establishes and promotes basic and translational research interest in the field of intraperitoneal drug delivery, which has the potential to improve the outcome for this dreaded condition. Edited by two renowned surgical oncologists, it represents the definitive reference in the field of intraperitoneal cancer therapy.

Features

• Encompasses all aspects from basic science (anatomy and physiology) to clinical aspects of diagnosis and treatment of peritoneal cancer
• Features editors who are leading figures in the field of intraperitoneal cancer with chapters contributed by an international team of experts from North America, Europe, and elsewhere
• Discusses the latest advances in the rapidly growing field of intraperitoneal cancer therapy
• Appeals both to clinical oncologists (surgical, gynecological, and medical) and researchers seeking a reliable and up-to-date reference

Contents

PERITONEUM: EMBRYOLOGY, ANATOMY, AND PHYSIOLOGY

Embryology and Anatomy of the Peritoneal Cavity
Jesus Esquivel

Structure and Function of the Mesothelial Cell
Steven E. Mutsaers, Cecilia M. Prêle, and Sarah E. Herrick

Applied Radiological Anatomy of the Peritoneal Cavity
Katie Planche

Peritoneal Drug Transport
Michael F. Flessner

PERITONEAL CARCINOMATOSIS: BASIC MECHANISMS

Molecular Biology of Peritoneal Carcinomatosis
Riom Kwakman, Nina R. Sluiter, Erienne M.V. de Cuba, and Elisabeth (Lisette) A. te Velde

Dissemination and Adhesion of Peritoneal Cancer Cells to the Peritoneal Wall
Elly De Vlieghere, Marc Bracke, Laurine Verset, Pieter Demetter, and Olivier De Wever

Genomic Approaches to Peritoneal Carcinomatosis
Haroon A. Choudry and David L. Bartlett

Surgery, Wound Healing, and Peritoneal Minimal Residual Disease in Colorectal Cancer
Wim P. Ceelen

Role of the Greater Omentum in the Pathogenesis of Peritoneal Carcinomatosis
Manuel J. Koppe

Lymphatic Transport and the Diaphragmatic Stomata
Katharina G.M.A. D’Herde

INTRAPERITONEAL DRUG THERAPY: BASIC PRINCIPLES

Pharmacokinetics of Intraperitoneal Cytotoxic Drug Therapy
Kurt Van der Speeten

Tissue Transport and Pharmacodynamics of Intraperitoneal Chemotherapy
Pieter Colin, Félix Gremonprez, and Wim P. Ceelen

Mathematical Models of Intraperitoneal Drug Delivery
Joanna Stachowska-Pietka and Jacek Waniewski

SURGICAL TECHNIQUES FOR INTRAPERITONEAL DRUG DELIVERY

Management of Peritoneal Metastases Using Cytoreductive Surgery and Perioperative Chemotherapy
Paul H. Sugarbaker

Chemoperfusion Techniques and Technologies
Kiran Turaga

Port Placement for Intraperitoneal Chemotherapy
Lisa M. Landrum and Joan L. Walker

CLINICAL RESULTS OF INTRAPERITONEAL DRUG DELIVERY

Intraperitoneal Chemotherapy for Ovarian Cancer
Abdulrahman Sinno and Deborah Armstrong

Cytoreductive Surgery and HIPEC in the Treatment of Advanced Epithelial Ovarian Cancer and Serous Papillary Peritoneal Carcinoma
Deraco Marcello, Kusamura Shigeki, and Baratti Dario

Pseudomyxoma Peritonei
Bettina Lieske and Brendan Moran

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer with Peritoneal Surface Disease
Edward A. Levine and Chukwuemeka Obiora

Diffuse Malignant Peritoneal Mesothelioma: Current Concepts in Evaluation and Management
Keli M. Turner and H. Richard Alexander, Jr

Gastric Cancer and Intraperitoneal Chemotherapy
Valerie Francescutti, John M. Kane III, and Joseph J. Skitzki

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma
Edward A. Levine

Peritoneal Surface Malignancy from Neuroendocrine Tumors
Mladjan Protic, Itzhak Avital, and Alexander Stojadinovic

Treatment Considerations for High-Grade Appendiceal Adenocarcinoma
Sean P. Dineen, Melissa Taggart, Richard E. Royal, Paul Mansfield, and Keith F. Fournier

Systemic Therapy for Appendiceal Cancer
Jennifer L. Zadlo and Cathy Eng

Toxicity and Morbidity of IP Drug Therapy
Colette Pameijer

Safety Considerations and Occupational Hazards
Joel M. Baumgartner, Kaitlyn J. Kelly, and Andrew M. Lowy

Role of CRS/HIPEC in the Management of Malignant Ascites
Konstantinos I. Votanopoulos

NOVEL AND EXPERIMENTAL APPROACHES

Development of Drug-Loaded Particles for Intraperitoneal Therapy
Ze Lu, M. Guillaume Wientjes, and Jessie L.-S. Au

Biomaterials and Drug Delivery Systems for Intraperitoneal Chemotherapy
Bo Sun and Yoon Yeo

Intraperitoneal Nonviral Nucleic Acid Delivery in the Treatment of Peritoneal Cancer
George R. Dakwar, Stefaan S.C. De Smedt, and Katrien Remaut

Immunotherapy of Peritoneal Carcinomatosis
Michael A. Ströhlein and Markus M. Heiss

The Promise of Oncolytic Viral Therapy for the Treatment of Peritoneal Surface Malignancies
John H. Stewart, IV and Lauren Gillory

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Marc A. Reymond, W. Solass, and C. Tempfer

Authors

Wim P. Ceelen, MD, PhD, professor of surgery, Ghent University Hospital, Belgium

Edward Levine, MD, professor of surgery and chief of surgical oncology, Wake Forest University, Winston-Salem, USA