Adverse Drug Interactions: A Handbook for Prescribers

Description

Adverse Drug Interactions: A Handbook for Prescribers assists clinicians byproviding key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use.

Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted. Less threatening but nonetheless important interactions necessitating practical measures, such as frequent monitoring and advice to patients, are also discussed.

Presented in a user-friendly format, the book is organised by drug class and provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse effects occur. 

All interactions listed in the previous edition have been reviewed and updated using the latest information available. The clinical reality of the widespread use of potent medicines, whether allopathic, herbal or traditional, has led to the inclusion of a chapter specifically addressing over-the-counter drugs and remedies.

Importantly, the increasing relevance of drug interactions due to genetic polymorphisms of metabolizing enzymes and drug transporters and the associated influence of these in ethnic groups is discussed. Also discussed is the risk of interactions in many vulnerable population groups (e.g. infancy, pregnancy, infections, liver and kidney disease).

This quick and easy reference guide brings together the current evidence base with a broad range of practical prescribing experience to produce a source of advice that can be used in the clinic, pharmacy, or at the patient’s bedside.

Features

• Provides a list of the most common medications associated with adverse drug interactions
• Serves as a comprehensive, clinically based, and user-friendly guide for the early detection of reactions
• Covers nutritional supplements and over-the-counter therapeutic agents
• Provides instructions for monitoring patients when adverse interactions occur
• Provides summaries of the mechanisms underlying interactions particularly the increasingly recognized role of genetics and the ethnic differences in pharmacokinetics

Contents

Drugs Acting on the Cardiovascular System
Simon F.J. Clarke

Drugs Acting on the Central Nervous System
Lakshman Delgoda Karalliedde and Harini Genegedera 

Anticancer and Immunomodulating Drugs
Patrick Yong

Anticoagulants
Rebecca Chanda

Antidiabetic Drugs
Yohan P. Samarasinghe and Janaka Karalliedde

Other Endocrine Drugs
Ming Ming Teh and Yohan P. Samarasinghe

Analgesics
Ruwan Parakramawansha

Musculoskeletal Drugs
Winglam Yeung

Anesthetic Drugs: General
Vasanthi Pinto and E. Queenie Veerasingam

Drugs to Treat Infections
Ursula Collignon

Drugs Acting on the Gastrointestinal Tract
Ursula Collignon

Respiratory Drugs
Lakshman Delgoda Karalliedde and Simon F.J. Clarke

Metabolic Drugs
Simon F.J. Clarke

Obstetrics and Gynecology
Gregory Ian Giles and Simon F.J. Clarke

Drugs Used to Treat the Urinary System
Simon F.J. Clarke

Drugs of Abuse
Lakshman Delgoda Karalliedde and Janaka Karalliedde

Miscellaneous
Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Over-the-Counter/Online Drugs, Traditional and Herbal Remedies
Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Appendices:

Factors Associated with Drug Effects
Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

Factors Associated with Interactions (Polymorphisms, Ethnicity, Age, Disease States)
Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

Foods Implicated in Potentially Severe Interactions
Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

Clinical Drug Development
Lakshman Delgoda Karalliedde and Janaka Karalliedde

Assessments of Manifestations of DDIs
Simon F.J. Clarke and Ursula Collignon

Triptan Sensations
Lakshman Delgoda Karalliedde and Janaka Karalliedde

Assessment of Severity of Liver Disease
Chulananda Goonasekera

Prescribing Guidelines for Elderly Patients
Andrea Corsonello and Giuseppe Maltese

Factors Affecting Efficacy of Anti-Infective Agents
Niroshini Manthri Giles and Lakshman Delgoda Karalliedde

Assessments of Obesity
Lakshman Delgoda Karalliedde and H.M.U. Amila Jayasinghe

Editor(s) Bio

Lakshman Delgoda Karalliedde, visiting professor, Faculty of Medicine Peradeniya, Sri Lanka, and visiting senior lecturer, King’s College London, UK

Simon Clarke, Frimley Park NHS Foundation Trust, Camberley, UK

Ursula Gotel nee Collignon, St. Thomas' Hospital, London, UK

Janaka Karalliedde, King's College London School of Medicine, UK