Translational Research in Traumatic Brain Injury

Description

Translational Research in Traumatic Brain Injury is designed to address the key issues in the epidemiology, basic science, and treatment of traumatic brain injury (TBI). Edited by two clinically active physician scientists, the book presents contributions from faculty who are international leaders in the areas of molecular biology, translational modeling, treatment, and rehabilitation of traumatic brain injury.

The book covers a wide scope of TBI research critically important to the neurobiology research community, clinicians involved in the care of TBI patients, as well as industry leaders interested in developing new therapies for acute brain injury. It examines the full spectrum of TBI events, from mild sports-related injuries to severe blast injuries. It discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments. The book also describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder.

Features

• Covers the spectrum of TBI, from mild sports-related injuries to severe blast injuries
• Discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments
• Describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder
• Written by international leaders across multiple disciplines, including neurobiology, neurology, neurosurgery, intensive care medicine, psychiatry, and rehabilitative medicine

Table of Contents

Epidemiology
Epidemiology
Sports Injury

Pathophysiology
Diffuse Axonal Injury
BBB Breakdown
Cellular
Neuroplasticity after TBI
Neuroinflammation
Neurosteroids
Genetics of TBI
Acute Neuronal Excitability and Seizures after TBI
Animal Models

Diagnosis of TBI
Biomarkers
Radiology

Current Treatment and Sequelae
Current Therapeutic Strategies
Epilepsy after TBI
Neurocognitive Sequelae and Relationship to PTSD
Management and Monitoring of Cerebral Physiology and ICP

Clinical Trials and Future Therapies
Clinical Trials in TBI
Clinical Trials in PTSD
Cell-based Therapies in TBI
Neurostimulation
Machine/Brain Interface