Cancer Biomarkers: Minimal and Noninvasive Early Diagnosis and Prognosis

Description

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers.

It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information.

Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume

The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers.

Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis

• Presents noninvasive early molecular markers in urological cancers
• Describes gynecological and endocrine cancer markers
• Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers
• Addresses hematological malignancies
• Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma
• Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma

This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Features

• Presents most recent data and all promising current and upcoming early diagnostic noninvasive molecular markers
• Introduces, in each chapter, physicians or scientists that have leading roles in respective cancer biomarker discoveries
• Provides a readily available resource for doctors, clinicians, health care industries to recommend or develop early diagnostic and at-risk tests for various cancers
• Affords use to cancer researchers for developing next-generation biomarkers, targets, and targeted therapeutics for various cancers
• Contains information on biomarker market economics, test providers, patent information, etc.

Table of Contents

Part I General and Technical Aspects

Quality Control and Ethical Issues of Cancer Biomarker Discovery
Anjana Munshi and Vandana Sharma

Imaging Techniques in Cancer Diagnosis
Mohamed Abd El-Salam, Sonia Reda, Salwa Lotfi, Tamar Refaat, and Eman El-Abd

Role of PET in Cancer Diagnosis
Silvia Taralli, Antonella Stefanelli, and Giorgio Treglia

Innovative Tools for Early Detection of Cancer
Ali Tiss, Amal Hasan, Abdelkrim Khadir, Mohammed Dehbi, and Said Dermime

Noninvasive Nanodiagnostics for Cancer
Sandhiya Selvarajan, Melvin George, and Suresh Kumar

Mitochondrial DNA in Early Cancer Diagnosis and Screening
Mukesh Verma, Neelesh Agarwal, and Mudit Verma

Circulating miRNA Biomarkers in Various Solid Cancers
Martina Redova, Hana Mlcochova, and Ondrej Slaby

Stem Cell Biomarkers in Early Diagnosis, Prognosis, and Therapy of Cancer
Dipali Dhawan and Harish Padh

Salivary Biomarkers in Early Diagnosis and Monitoring of Cancer
Saroj K Basak and Eri S Srivatsan

Part II Brain and Head and Neck Cancers

Biomarkers for Brain Gliomas
Yusuf Izci

Noninvasive Biomarkers in Head and Neck Squamous Cell Carcinoma
Anand Kumar, Mumtaz Ahmad Ansari, and Vivek Srivastava

Biological Markers in Oral Squamous Cell Carcinoma
Mario Pérez-Sayáns García, Danielle Resende Camisasca, Abel García García, Simone de Queiroz Chaves Lourenço, and Anastasios Markopoulos

Part III Gastrointestinal Cancers

Biomarkers for Gastric Cancer and the Related Premalignant Conditions
Marcis Leja, Jan Bornschein, Juozas Kupcinskas, and Peter Malfertheiner

Biomarkers in Esophageal Adenocarcinoma
Simon JW Monkhouse, J Muhlschlegel, and H Barr

Biomarkers for Diagnosis and Metastasis of Hepatocellular Carcinoma
Dengfu Yao, Min Yao, Xiaodi Yan, Li Wang, and Zhizhen Dong

Noninvasive Early Markers in Gallbladder Cancer
Mumtaz Ahmad Ansari, Ruhi Dixit, and Vijay Kumar Shukla

Noninvasive Early Markers in Pancreatic Cancer
Aleksandra Nikolic

Part IV Lung Cancer and Mesothelioma

Noninvasive Early Markers in Lung Cancer
Mukesh Verma, Debmalya Barh, and Neha Jain

Exhaled Volatile Organic Compounds as Noninvasive Early Molecular Markers in Lung Cancer: Bridging the Gap from Bench to Bedside
Meggie Hakim, Ulrike Tisch, Michael Unger, and Hossam Haick

Part V Urological Cancers

Noninvasive Early Molecular Biomarkers in Kidney Cancer
Brian W Cross, Jonathan Huang, and Viraj A Master

Novel Oncomarkers Used for Earlier Detection of Bladder Carcinoma
Miroslava Bilecová-Rabajdová, Peter Urban, Mária Mareková, and Vincent Nagy

Screening for Prostate Cancer: New Markers and Future Aspects
Nigel P Murray

Part VI Gynecological and Endocrine Cancers

Early Biomarkers in Breast Cancer
Ruchika Kaul-Ghanekar, Snehal Suryavanshi, and Prerna Raina

Noninvasive Biomarkers in Ovarian Cancer
Sharon A O’Toole, Eugen Ancuta, Ream Langhe, Dolores J Cahill, Mairead Murphy,

Cara Martin, Lynda McEvoy, Cathy Spillane, Orla Sheils, Emmanuel Petricoin,
Lance Liotta, and John J O’Leary

Early Markers for Neoplastic Lesions of the Uterine Cervix
Pablo Conesa-Zamora

Biomarkers in Diagnosis of Papillary Thyroid Carcinoma
Marisa Cañadas-Garre, Nuria Muñoz Pérez, Jesús Maria Villar del Moral, José Antonio Ferrón Orihuela, and José Manuel Llamas-Elvira

Biomolecular Markers for Improving Management of Follicular and Medullary Thyroid Cancer
Umut Mousa, Cuneyd Anil, Serife Mehlika Isildak, Alptekin Gursoy, and Angelo Carpi

Part VII Hematological Cancers

Biomarkers in Myelodysplastic Syndrome
Néstor L López Corrales and Vasco Ariston de Carvalho Azevedo

Markers for Diagnosis, Prognosis, and Therapy of Acute Myeloid Leukemia
Ota Fuchs

Biomarkers in Hodgkin’s Lymphoma
Esin Demir, Burak Yilmaz, Mehmet Gunduz, and Esra Gunduz

Multiple Myeloma and Evolution of Novel Biomarkers and Therapies
Michael Byrne, Joseph Katz, and Jan S Moreb

Part VIII Melanoma

Diagnostic and Prognostic Biomarkers in Cutaneous Melanoma
Eijun Itakura and Alistair J Cochran

Index

Editor Bio(s)

Debmalya Barh
Scientist
Institute of Integrative Omics and Applied Biotechnology - IIOAB
Nonakuri West Bengal India
We work towards integrative omics based target and targeted drug discovery, biomarkers, pharmacogenomics, cancer, neuro, CVDs, infectious, and metabolic diseases, and plant, animal, and environmental biotechnology

Areas of Research / Professional Expertise

Bioinformatics, Integrative omics based target and targeted drug discovery, pharmacogenomics, cancer, neuro, CVDs, metabolic diseases, and plant, animal, and environmental biotechnology