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Handbook of Small Animal Imaging. Preclinical Imaging, Therapy, and Applications
Kagadis, G. — Ford, N. — Karnabatidis, D. — Loudos, G.
1ª Edición Abril 2016
Inglés
Tapa dura
602 pags
2000 gr
21 x 28 x null cm
ISBN 9781466555686
Editorial CRC PRESS
LIBRO IMPRESO
-5%
350,46 €332,94 €IVA incluido
336,98 €320,13 €IVA no incluido
Recíbelo en un plazo de
2 - 3 semanas
Description
The use of small animal models in basic and preclinical sciences constitutes
an integral part of testing new pharmaceutical agents prior to their application
in clinical practice. New imaging and therapeutic approaches need to be tested
and validated first in animals before application to humans.
Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications
collects the latest information about various imaging and therapeutic technologies
used in preclinical research into a single source. Useful to established researchers
as well as newcomers to the field, this handbook shows readers how to exploit
and integrate these imaging and treatment modalities and techniques into their
own research.
The book first presents introductory material on small animal imaging, therapy,
and research ethics. It next covers ionizing radiation and nonionizing radiation
methods in small animal imaging, hybrid imaging, and imaging agents. The book
then addresses therapeutic research platforms and image quantification, explaining
how to ensure accurate measurements of high-quality data. It concludes with
an overview of many small animal imaging and therapy applications that demonstrate
the strength of the techniques in biomedical fields.
Features
- Covers all aspects of preclinical imaging, from initiating a research program using animals to analyzing imaging data and methods
- Provides practical information on animal ethics, models, and handling to assist researchers in planning and executing their small animal imaging studies
- Explains how to measure and quantify images
- Explores a broad spectrum of disease types and disease sites where small animal imaging and therapy are currently applied, including cardiovascular disease and intracellular targets
Reviews
"A great overview of current small animal imaging modalities describing
their principles of operation, equipment components, and most recent applications
with extremely helpful illustrations. An essential book for every biologist,
chemist, and physicist involved in small animal research."
—Magdalena Bazalova-Carter, PhD, Department of Physics and Astronomy,
University of Victoria
"… a superb, comprehensive, and very accurate depiction of the state
of the art in small animal imaging technologies and applications. This is an
authoritative book and invaluable source of information for all biomedical sciences
and technologies students, as well as for educators, professionals, and researchers
in this multidisciplinary field."
—Professor George Kontaxakis, Universidad Politécnica de Madrid
Contents
INTRODUCTION TO SMALL ANIMAL IMAGING, THERAPY, AND APPLICATIONS
Defining Small Animal Imaging, Therapy, and Applications
Nancy L. Ford, George K. Loudos, Dimitrios N. Karnabatidis, and George C. Kagadis
Ethics and Regulations for Research with Animals
William R. Hendee
Small Animal Handling, Care, and Anesthesia
Tamara Godbey
Preclinical Models
Irene Cuadrado, Jesús Egido, Jose Luis Zamorano, and Carlos Zaragoza
SMALL ANIMAL IMAGING: IONIZING RADIATION
Microcomputed Tomography
Nancy L. Ford
Digital Subtracted Angiography of Small Animals
Stavros Spiliopoulos, George C. Kagadis, Dimitrios N. Karnabatidis, G. Allan
Johnson, and Cristian Badea
Single-Photon Emission Computed Tomography
Matthew A. Lewis
Positron Emission Tomography
Vesna Sossi and Matthew Walker
SMALL ANIMAL IMAGING: NONIONIZING RADIATION
MR Imaging
Dmitri Artemov
Optical Imaging
Matthew A. Lewis
HYBRID IMAGING
Optical-CT Imaging
Xueli Chen, Dongmei Chen, FengLin Liu, Wenxiang Cong, Ge Wang, and Jimin Liang
PET/CT
Mohammad Reza Ay and Nafiseh Ghazanfari
Introduction to Combining MRI with PET
Volkmar Schulz, Jakob Wehner, and Yannick Berker
Exotic Imaging Approaches
Maria Koutsoupidou and Irene S. Karanasiou
IMAGING AGENTS
X-Ray, MRI, and Ultrasound Agents: Basic Principles
Michael F. Tweedle, Krishan Kumar, and Michael V. Knopp
Radiochemistry for Preclinical Imaging Studies
Sven Macholl and Matthias Glaser
Molecular Targets and Optical Probes
Eleni K. Efthimiadou and George Kordas
THERAPEUTIC RESEARCH PLATFORMS
Developing Technologies for Small Animal Radiotherapy
Frank Verhaegen, James Stewart, and David Jaffray
Dosimetry of Ionizing Radiation in Small Animal Imaging
Michael G. Stabin
Treatment Planning for Small Animals
Frank Verhaegen
Radiolabeled Agents for Molecular Imaging and/or Therapy
Dimitrios Psimadas and Eirini A. Fragogeorgi
IMAGE QUANTIFICATION
Quantification in Nuclear Preclinical Imaging
Istvan Szanda
Performance Assessment of Small Animal Imaging Systems and Common Standards
Nancy L. Ford
Monte Carlo Simulations in Imaging and Therapy
Panagiotis Papadimitroulas, George C. Kagadis, and George K. Loudos
APPLICATIONS: INCLUDES BOTH IMAGING AND THERAPY
Small Animal Imaging and Therapy: How They Affect Patient Care
Lawrence W. Dobrucki
Applications for Drug Development
Jeßica Kalra, Donald T. Yapp, Murray Webb, and Marcel B. Bally
Imaging of Intracellular Targets
Veerle Kersemans
Imaging of Cell Trafficking and Cell Tissue Homing
Veerle Kersemans
Imaging of Cardiovascular Disease
Aleksandra Kalinowska and Lawrence W. Dobrucki
Imaging Angiogenesis
Lawrence W. Dobrucki
Imaging of Hypoxia, Apoptosis, and Inflammation
Stavros Spiliopoulos and Athanasios Diamantopoulos
Vessel Wall Imaging
Stavros Spiliopoulos
Authors
George C. Kagadis, PhD, FAAPM, is an associate professor of
medical physics and medical informatics at the University of Patras. He also
holds an adjunct assistant professor appointment at the University of Texas
MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee,
a Fulbright research scholar, and a fellow of the American Association of Physicists
in Medicine (AAPM). He has authored about 80 journal papers and presented at
more than 20 conferences. He received his PhD in medical physics from the University
of Patras. His current research interests focus on medical image processing
and analysis, studies in molecular imaging, IHE, and CAD applications.
Nancy L. Ford, PhD, is an assistant professor in the Department
of Oral, Biological and Medical Sciences and the director of the Centre for
High-Throughput Phenogenomics at the University of British Columbia. She is
a full member of the AAPM and an associate editor of Medical Physics. She publishes
in journals on medical physics, radiology, and dental science. She received
her PhD in medical biophysics from the University of Western Ontario. Her research
focuses on preclinical micro-computed tomography imaging and image-based analysis,
primarily studying models of respiratory diseases, along with CBCT and MSCT
for medical and dental applications.
Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor
of interventional radiology at the University of Patras. He is a fellow of the
Cardiovascular and Interventional Radiological Society of Europe and a member
of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology,
and the Western Greece Radiology Society. He has been involved as a participant/principal
investigator in several national/international research projects and has published
122 articles in peer-reviewed journals. He received his PhD from the School
of Medicine, University of Patras. His research interests include angiogenesis
in malignant and benign diseases, the augmentation of arteriogenesis in critical
limb ischemia, endothelial hyperplasia inhibition after endovascular procedures,
and ureteral obstructive diseases.
George K. Loudos, PhD, is an assistant professor in the Department
of Biomedical Engineering at the Technological Educational Institute of Athens.
He has published 89 articles in international journals and more than 200 papers
in conference proceedings. He received his PhD in biomedical engineering from
the National Technical University of Athens. His research interests focus on
molecular imaging using nuclear medicine techniques and medical instrumentation.
He strongly supports interdisciplinary cooperation and education in the field
of nanomedicine and molecular imaging.
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