Nathan and Oski's Hematology and Oncology of Infancy and Childhood, 2 Vols. (Online and Print)

Description

Written by the leading names in pediatric oncology and hematology, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children.

New to this edition

• Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics.
• Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology.
• Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field.
• Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

Key Features

• Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones.
• Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children.
• Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume.

Contents

Section I Neonatal Hematology

• 1. Anatomy and Physiology of Hematopoiesis
• 2. The Neonatal Erythrocyte and Its Disorders
• 3. Immune Hemolytic Disease
• 4. Neonatal Jaundice and Disorders of Bilirubin Metabolism
• 5. Hemostasis in the Newborn and Infant

Section II Bone Marrow Failure

• 6. Acquired Aplastic Anemia and Pure Red Cell Aplasia
• 7. Inherited Bone Marrow Failure Syndromes
• 8. Principles of Bone Marrow and Stem Cell Transplantation

Section III Disorders of Erythrocyte Production

• 9. Diagnostic Approach to the Anemic Patient
• 10. Megaloblastic Anemia
• 11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity
• 12. Porphyrias

Section IV Hemolytic Anemias

• 13. Autoimmune Hemolytic Anemia
• 14. Paroxysmal Nocturnal Hemoglobinuria
• 15. Red Cell Membrane
• 16. Disorders of the Red Cell Membrane
• 17. Pyruvate Kinase Deficiency and Disorders of Glycolysis
• 18. Glucose-6-Phosphate Dehydrogenase Deficiency
• 19. Normal and Abnormal Hemoglobins

Section V Disorders of Hemoglobin

• 20. Sickle Cell Disease
• 21. Thalassemias

Section VI Phagocyte System

• 22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function

Section VII Immune System

• 23. Immune Response
• 24. Primary Immunodeficiency Diseases

Section VIII Storage Diseases

• 25. Lysosomal Storage Diseases

Section IX Hemostasis

• 26. Platelets and the Vessel Wall
• 27. Blood Coagulation
• 28. Molecular Basis of Fibrinolysis
• 29. Approach to the Child with a Suspected Bleeding Disorder
• 30. Inherited Platelet Disorders
• 31. Hemophilia and von Willebrand Disease
• 32. Rare Hereditary Coagulation Factor Abnormalities
• 33. Inherited Disorders of Thrombosis and Fibrinolysis
• 34. Acquired Platelet Defects
• 35. Acquired Disorders of Hemostasis

Section X Supportive Therapy

• 36. Transfusion Medicine

Section XI Hematologic Manifestations of Systemic Diseases

• 37. Hematological Manifestations of Systemic Diseases
• 38. Hematology Manifestations of Systemic Diseases in Children of the Developing World

Section XII Biology of Cancer

• 39. Origins and Evolution of Pediatric Cancer
• 40. Epidemiology of Leukemia in Childhood
• 41. Informatics
• 42. Genetic Predisposition to Cancer
• 43. Genetic and Epigenetics of Childhood Cancers
• 44. Targeted Therapies in Oncology
• 45. Cytogenetic and Molecular Pathology of Pediatric Cancer

Section XIII Pediatric Cancer Therapeutics

• 46. Cancer Chemotherapy for Pediatric Patients
• 47. Immunotherapy of Cancer
• 48. Pediatric Radiation Oncology
• 48. Pediatric Surgical Oncology

Section XIV Hematologic Malignancy

• 50. Acute Lymphoblastic Leukemia
• 51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease
• 52. Infant Leukemias
• 53. Pediatric Lymphoma

Section XV Solid Tumors

• 54. Neuroblastoma
• 55. Pediatric Renal Tumors
• 56. Retinoblastoma
• 57. Tumors of the Brain and Spinal Cord
• 58. Hepatoblastoma and Other Liver Tumors in Children
• 59. Rhabdomyosarcoma
• 60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors
• 61. Ewing Sarcoma
• 62. Osteosarcoma
• 63. Pediatric Germ Cell Tumors
• 64. Histiocytoses
• 65. Rare Tumors of Childhood
• 66. Imaging in the Evaluation and Management of Childhood Cancer

Section XVI Supportive Care

• 67. Infectious Disease in the Pediatric Cancer Patient
• 68. Oncologic Emergencies
• 69. Nursing Care of Patients with Childhood Cancer
• 70. Palliative Care in Pediatric Oncology
• 71. Symptom Management in Children with Cancer
• 72. Childhood Cancer Survivorship
• 73. Psychosocial Care of the Child and Family
• 74. Ethical Considerations in Pediatric Oncology Clinical Trials

Appendices: Reference Values in Infancy and Childhood

Author Info

By Stuart H. Orkin, MD, David G Nathan Professor of Pediatrics, Harvard Medical School; Chair, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital; Investigator, Howard Hughes Medical Institute, Boston, Massachusetts ; David G. Nathan, MD, President Emeritus, Dana-Farber Cancer Institute, Physician-in-Chief Emeritus, Boston Children's Hospital; Stranahan Distinguished Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, Massachusetts ; David Ginsburg, MD, James V Neel Distinguished University Professor, Departments of Internal Medicine, Pediatrics, and Communicable Diseases, and Human Genetics, Investigator, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan ; A. Thomas Look, MD, Professor of Pediatrics, Harvard Medical School; Vice Chair for Research, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts ; David E. Fisher, MD, PhD, Chief, Department of Dermatology, Director, Cutaneous Biology Research Center, Massachusetts General Hospital; Director, Melanoma Program, Massachusetts General Hospital Cancer Center, Boston, Massachusetts and Samuel Lux, IV, MD, Robert A Stranahan Professor of Pediatrics, Harvard Medical School; Chief Emeritus, Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts