Uicc Manual of Clinical Oncology

Description

The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world.

Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care.

Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the TNM Classification of Malignant Tumours.

The ninth edition includes:

Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments,
Representation of multidisciplinary care for site specific management,
Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines,
State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and
Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy.

Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.

Contents

Foreword
Preface
About the Editors
Contributors

PART 1 General principles of cancer diagnosis and management 1

Principles of knowledge generation and translation

• 1 – Cancer epidemiology 3
• 2 – Levels of evidence, guidelines and standards 12
• 3 – Prognosis and classification of cancer 23
• 4 – Principles of cancer staging 34
• 5 – Assessment of treatment outcome 40
• 6 – Cancer informatics 53

Principles of cancer diagnosis

• 7 – Imaging 63
• 8 – Pathology 83

Principles of treatment

• 9 – Principles of surgery 98
• 10 – Principles of radiotherapy 108
• 11 – Principles of systemic therapy 124

Special settings, supportive care and survivorship

• 12 – Treatment in pregnancy 134
• 13 – Treatment in the elderly 139
• 14 – Oncology emergencies 145
• 15 – Supportive care during curative treatment 155
• 16 – Pain management in cancer 168
• 17 – Palliative care 174
• 18 – Survivorship 184
• 19 – Rehabilitation 194

PART 2 Site-specific multidisciplinary cancer management 203

Thoracic malignancies

• 20 – Lung 205

Breast

• 21 – Breast 221

Gastrointestinal malignancies

• 22 – Liver 241
• 23 – Biliary tract and pancreas 263
• 23.1 – Biliary tract 263
• 23.2 – Pancreas 270
• 24 – Oesophagus 280
• 25 – Stomach 297
• 26 – Colon, rectum and anus 308
• 26.1 – Colon and rectum 308
• 26.2 – Anus 327

Genitourinary malignancies

• 27 – Prostate 333
• 28 – Bladder and other urothelium 343
• 29 – Kidney 354
• 30 – Testicular germ cell tumours 368
• 31 – Penis 384

Haematological malignancies

• 32 – Lymphoma 392
• 33 – Myeloma 415
• 34 – Leukaemia 427

Gynaecological cancers

• 35 – Cervix 449
• 36 – Uterus 467
• 37 – Ovary and fallopian tube 479

Head and neck cancer

• 39 – General principles of head and neck cancer management 503
• 40 – Nasopharynx 512
• 41 – Oral cavity 524
• 42 – Larynx and hypopharynx 542
• 43 – Oropharynx 559
• 44 – Major salivary glands 571
• 45 – Nasal cavity and paranasal sinus 586
• 46 – Head and neck unknown primary 597

Endocrine tumors

• 47 – Pituitary 609
• 48 – Thyroid 626
• 49 – Adrenal tumours 641
• 50 – Neuroendocrine tumours 656

Dermatological cancer

• 51 – Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma 674
• 52 – Melanoma 689

Central nervous system and ocular cancers

• 53 – Central nervous system 706
• 54 – Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymph

Sarcoma

• 55 – Bone (osteosarcoma) 745
• 56 – Soft tissue 754

Childhood malignancies

• 57 – Paediatric tumors 768

Specific cancer situations

• 58 – Cancer of unknown primary (no 59 – HIV and transplant-related neoplasms 797
• 59.1 – HIV-related neoplasms 797
• 59.2 – Post-transplantation lymphoproliferative disease 809
• 59.3 – Cancer following solid organ transplantation 812

Index 815

Authors

Brian O’Sullivan, MD, FRCPC, FRCPI, FFRRCSI (Hon), FASTRO (Editor-in-Chief)
Professor, Department of Radiation Oncology
Bartley-Smith / Wharton Chair in Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto
Toronto, Ontario, Canada

James D Brierley, BSc, MB, FRCP, FRCR, FRCPC (Associate Editor)
Professor, Department of Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto
Toronto, Ontario, Canada

Anil K. D’Cruz MS, DNB, FRCS (Associate Editor)
Professor, Department of Head and Neck Surgical Oncology
Tata Memorial Hospital, Mumbai, India

Martin F. Fey, MD (Associate Editor)
Professor, Department of Medical Oncology
Inselspital and University Hospital
Bern, Switzerland

Raphael Pollock, MD, PhD (Associate Editor)
Director of Surgical Oncology, Chief of Surgical Services
The James NCICCC/Ohio State University
Columbus, OH, USA

Jan B. Vermorken, MD, PhD (Associate Editor)
Emeritus Professor of Oncology
Faculty of Medicine and Health Sciences,
University of Antwerp, Antwerp, Belgium
Department of Medical Oncology
Antwerp University Hospital
Edegem, Belgium

Shao Hui Huang, MD, MSc, MRT(T) (Editorial coordinator)
Assistant Professor
Department of Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto