Inflammation and Allergy Drug Design

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DESCRIPTION

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.

This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

TABLE OF CONTENTS

• Contributors, vii
• Preface, xiii

Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract

• 1. Novel anti-infl ammatory drugs based on targeting lung dendritic cells and airway epithelial cells, 3
  Bart N. Lambrecht, Maud Plantinga, Monique Willart, and Hamida Hammad
• 2. Role of Th2 cells in the allergic diathesis, 15
  Marsha Wills-Karp
• 3. Importance of Th17- and Th1-associated responses for the development of asthma, 27
  Tomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi
• 4. Regulatory T cells, 39
  Chris Corrigan and Kimuli Ryanna
• 5. A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders, 59
  Hiroshi Watarai, Michishige Harada, Mayumi Tamari, and Masaru Taniguchi
• 6. Regulatory roles of B cells in allergy and infl ammation, 67
  Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai
• 7. Mast cells, 79
  Mindy Tsai and Stephen J. Galli
• 8. Eosinophils, 107
  Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I. Ochkur
• 9. Basophils in infl ammation and allergy drug design, 123
  Donald MacGlashan, Jr.
• 10. Epithelial cells, 139
  Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, and Darryl Knight
• 11. Fibroblasts, 149
  Alastair G. Stewart, Lilian Soon, and Michael Schuliga
• 12. Airway smooth muscle cells, 163
  Andrew J. Halayko and Pawan Sharma

Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract

• 13. Interleukin 4, interleukin 13, and interleukin 9, 175
  Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi Suzuki
• 14. Interleukin 3, interleukin 5, and granulocyte–macrophage colony-stimulating factor, 187
  Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, and Manel Jordana
• 15. Interleukin 15, interleukin 17, and interleukin 25, 197
  Hiroshi Nakajima and Itsuo Iwamoto
• 16. Thymic stromal lymphopoietin, 205
  Kazuhiko Arima and Yong-Jun Liu
• 17. Interleukin 10, 215
  Whitney W. Stevens, Larry Borish, and John W. Steinke
• 18. Tumor necrosis factor alpha, 225
  Christopher Brightling, Latifa Chachi, Dhan Desai, and Yassine Amrani
• 19. Profi brotic and angiogenic factors in asthma, 237
  Neville Berkman and Francesca Levi-Schaffer
• 20. Chemokines, 253
  Luis M. Teran and Juan R. Velazquez
• 21. Epithelial growth factors, 263
  Yasuhiro Gon and Shu Hashimoto

Part III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract

• 22. Prostanoids, 273
  Sarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi
• 23. Leukotrienes, 285
  Katsuhide Okunishi and Marc Peters-Golden
• 24. Proteases in allergy, 297
  Keisuke Oboki and Hirohisa Saito
• 25. Toll-like receptors, 307
  Jessica L. Allen, Aurelien Trompette, and Christopher L. Karp

AUTHOR

K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan
Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK
Marsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA